JOURNAL CLUB

2024

  • Feb 22　(Shimakura); Feng, X., et al. (2023) Local membrane source gathering by p62 body drives autophagosome formation. Nat. Commun. 14 (1 ), 7338.

  • Feb 15　(Otomo); Hickey, K. L., et al. (2023) Proteome census upon nutrient stress reveals Golgiphagy membrane receptors. Nature 623 (7985), 167-174.
  • Jan 11　(Hadano); Zhang, S., et al. (2023) C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy. Nat. Commun. 14 (1), 6360.

    • 2023

  • Nov 9　(Wang); Miny, Y., et al. (2022) Modeling neurodegenerative diseases using in vitro compartmentalized microfluidic devices. Front. Bioeng. Biotechnol. 10, 919646.

  • Oct 25　(Shimakura); Leboeuf, M., et al. (2023) ENGRAILED-1 transcription factor has a paracrine neurotrophic activity on adult spinal alpha-motoneurons. EMBO Rep. 24 (8), e56525.

  • Oct 18　(Otomo); Shelke, G. V., et al. (2023) Inhibition of endolysosome fusion increases exosome secretion. J. Cell Biol. 222 (6), e202209084.

  • Sept 28　(Hadano); Kallergi, E., et al. (2023) Profiling of purified autophagic vesicle degradome in the maturing and aging brain. Neuron 111 (15), 2329-2347 e7.

  • Sept 21　(Wang); Sorrentino, S., et al. (2022) Neurovascular signals in amyotrophic lateral sclerosis. Curr. Opin. Biotechnol. 74, 75-83.

  • Sept 7　(Shimakura); Seidel, M., et al. (2023) Propranolol reduces the accumulation of cytotoxic aggregates in C9orf72-ALS/FTD in vitro models. Curr. Res. Neurobiol. 5, 100105.

  • July 20　(Otomo); Gallagher, E. R. & and Holzbaur, E. L. F. (2023) The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy. Cell Rep. 42 (2), 11203.7

  • July 13　(Hadano); Jimenez-Moreno, N., et al. (2023) ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience. J. Cell Biol. 222 (5), e20230300.8

  • July 6　(Wang); Osaki, T., et al. (2018) Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons. Sci. Adv. 4 (10), eaat5847.

  • June 29　(Shimakura); Rovira, R., et al. (2022) The lysosomal proteome of senescent cells contributes to the senescence secretome. Aging Cell 21 (10), e13707.

  • June 22　(Otomo); Schuhmacher, J. S., et al. (2023) The Rab5 effector FERRY links early endosomes with mRNA localization. Mol. Cell 83 (11), 1839-1855 e13.

  • June 15　(Hadano); Kurusu, R., et al. (2023) Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex. Dev. Cell 58, in press; DOI: 10.1016/j.devcel.2023.04.015.

  • June 8 (Wang); Marshall, K. L., et al. (2023) Enhanced axonal regeneration of ALS patient iPSC-derived motor neurons harboring SOD1(A4V) mutation. Sci. Rep. 13 (1), Pages 5597.

  • June 1 (Shimakura); Croft, C. L., et al. (2022) Optical pulse labeling studies reveal exogenous seeding slows alpha-synuclein clearance. NPJ Parkinsons Dis. 8 (1), Pages 173.

  • May 18 (Otomo); Neel, D. V., et al. (2023) Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration. Neuron 111 (8), 1222-1240 e9.

  • May 10 (Hadano); Baughn, M. W., et al. (2023) Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies. Science 379 (6637), 1140-1149.

  • Apr 20 (Wang); Park, J., et al. (2014) A microchip for quantitative analysis of CNS axon growth under localized biomolecular treatments. J. Neurosci. Methods 221, 166-174.

  • Apr 13 (Shimakura); Xia, Q., et al. (2023) Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy. Cell Biosci. 13 (1), Page 37.

  • Mar 30 (Otomo); Coelho, P. P., et al. (2022) Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation. Nat. Commun. 13 (1), Page 3812.
  • Mar 9 (Murakami); Stoklund Dittlau, K., et al. (2023) FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms. Mol. Neurodegener. 18 (1), Page 5.

  • Mar 2 (Hadano); Hung, S. T., et al. (2023) PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. Cell 186 (4), 786–802.e28.

  • Feb 9 (Yamaguchi); Morizawa, Y. M., et al. (2022) Synaptic pruning through glial synapse engulfment upon motor learning. Nat. Neurosci. 25 (11), 1458-1469.

  • Feb 2 (Yudahira); Stoklund Dittlau, K., et al. (2021) Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition. Stem Cell Rep. 16 (9), 2213-2227.

  • Jan 12 (Shimakura); Shimobayashi, S. F. & Ohsaki, Y. (2019) Universal phase behaviors of intracellular lipid droplets. Proc. Natl. Acad. Sci. U.S.A. 116 (51), 25440-25445.

  • List of past JOURNAL CLUBs