JOURNAL CLUB

2026

2025

  • Dec 25 (Shimakura); Aguirre, C., et al. (2025) Conformational switch in the alpha-synuclein C-terminal domain directs its fibril polymorphs. Chemistry 31 (37), e202500650.

  • Dec 11 (Otomo); Murata, H., et al. (2025) Carnosol, a rosemary ingredient discovered in a screen for inhibitors of SARM1-NAD(+) cleavage activity, ameliorates symptoms of peripheral neuropathy. Antioxidants 14, 808.

  • Nov 27 (Naoki); Ciuffreda, K. J. and Rutner, D. (2025) Visual Snow Syndrome: Therapeutic Implications. J. Clin. Med. 14, 6070.

  • Nov 13 (Iwasaki); De Vitis, E., et al. (2021) A microfabricated multi-compartment device for neuron and Schwann cell differentiation. Sci. Rep. 11 (1), 7019.

  • Nov 6 (Yudahira); Ye, L., et al. (2025) Sporadic ALS hiPSC-derived motor neurons show axonal defects linked to altered axon guidance pathways. Neurobiol. Dis. 206, 106815.

  • Nov 6 (Wang); Rotem, N., et al. (2017) ALS Along the Axons - Expression of Coding and Noncoding RNA Differs in Axons of ALS models. Sci. Rep. 7, 44500.

  • Oct 23 (Shimakura); Rubio-Atonal, L. F., et al. (2025) Glutamate decreases oxidative stress and lipid droplet formation in astrocytes. J. Cell Sci. in press.

  • Oct 9 (Hadano); Yan, X., et al. (2025) Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates. Cell 188 (15), 4123-4140.

  • Oct 2 (Otomo); Minowa-Nozawa, A., et al. (2025) RabGAP1L modulates Rab7A and Rab10 to orchestrate cell-autonomous immunity. Cell Rep. 44 (5), 115599.
  • July 31 (Iwasaki); Hiraiwa, T., et al. (2025) A human iPSC-Derived myelination model for investigating fetal brain injuries. Regen. Ther. 29, 100-107.

  • July 10 (Yudahira); Yanguas, F. and Progida, C. (2025) Rab21 recruits EEA1 and competes with Rab5 for Rabex-5 activation. Front. Cell. Dev. Biol. 13, 1588308.

  • July 3 (Wang); Zhu, D., et al. (2025) Pain-on-a-Chip: A microfluidic device for neuron differentiation and functional discrimination in animal models of chronic pain. Biosens. Bioelectron. 279, 117401.

  • June 26 (Shimakura); Chen, X. Q., et al. (2025) Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose. Alzheimers Dement. 21 (5), e70046.

  • June 19 (Hadano); Zhang, Z., et al. (2025) PTPsigma-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD. Neuron 113 (8), 1190-1205.

  • June 12 (Otomo); Li, A., et al. (2025) Endosomal protein DENND10 promotes developmental competence of neurite extension. iScience 28 (5), 112385.

  • May 29 (Mahvelati); Becerra, A. G., et al. (2022) Computing within bacteria: Programming of bacterial behavior by means of a plasmid encoding a perceptron neural network. Biosystems 213, 104608.

  • May 22 (Naoki); Strik, M, et al. (2025) Altered functional connectivity strength between structurally and functionally affected brain regions in visual snow syndrome. Brain Commun 7 (3), Pages fcaf171.

  • May 15 (Iwasaki); Liu, M, et al. (2024) Arched microfluidic channel for the promotion of axonal growth performance. iScience 27 (10), 110885.

  • May 8 (Yudahira); Fernandez Comaduran, F, et al. (2024) Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS. Cell Stress Chaperones 29 (3), 359-380.

  • May 1 (Wang); Wu, Z. Z., et al. (2006) Interfacing SH-SY5Y human neuroblastoma cells with SU-8 microstructures. Colloids Surf. B Biointerfaces 52 (1), 14-21.

  • Apr 17 (Shimakura); Trachsel-Moncho, L., et al. (2025) SNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics. J. Cell Biol. 224 (5), e202404009.

  • Feb 27 (Hadano); Handsaker, R. E., et al. (2025) Long somatic DNA-repeat expansion drives neurodegeneration in Huntington's disease. Cell 188 (3), 623-639.

  • Feb 13 (Shimakura); Hamamoto, K., et al. (2024) Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain. Cell Rep. 43 (12), 115016.

  • Feb 6 (Otomo); Smith, D. M., et al. (2024) Rab30 facilitates lipid homeostasis during fasting. Nat. Commun. 15 (1), 4469.

  • Jan 30 (Wang); Kim, K., et al. (2010) The optimization of PDMS-PMMA bonding process using silane primer. BioChip J. 4 (2), 148-154. / Borok, K., et al. (2021) PDMS Bonding Technologies for Microfluidic Applications: A Review. Biosensors (Basel) 11 (8), 292

  • Jan 16 (Hadano); De Decker, M., et al. (2024) C21ORF2 mutations point towards primary cilia dysfunction in amyotrophic lateral sclerosis. Brain awae331, https://doi.org/10.1093/brain/awae331.

  • Jan 9 (Shimakura); Noguchi, T., et al. (2023) LLPS of SQSTM1/p62 and NBR1 as outcomes of lysosomal stress response limits cancer cell metastasis. Proc. Natl. Acad. Sci.U.S.A. 120 (43), e2311282120.

    • 2024

  • Dec 26 (Otomo); Huilgol, D., et al. (2023) Direct and indirect neurogenesis generate a mosaic of distinct glutamatergic projection neuron types in cerebral cortex. Neuron 111 (16), 2557-2569.

  • Dec 19 (Wang); Ye, W., et al. (2020) 3D printing of gelatin methacrylate-based nerve guidance conduits with multiple channels. Mater. Des. 192, 108757.

  • Oct 31 (Murakami); Ogawa, T., et al. (2024) Formation and long-term culture of hiPSC-derived sensory nerve organoids using microfluidic devices. Bioengineering (Basel) 11 (8), 794.

  • Oct 17 (Hadano); Hutchings, A. J., et al. (2024) Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy. Nat. Commun. 15 (1), 8622.

  • Oct 10 (Shimakura); Cozzi, M., et al. (2024) Altered molecular and cellular mechanisms in KIF5A-associated neurodegenerative or neurodevelopmental disorders. Cell Death Dis. 15 (9), 692.

  • Sept 26 (Otomo); Scheiblich, H., et al. (2024) Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes. Neuron 112 (18), 3106-3125.e8.

  • Sept 19 (Murakami); Nebuloni, F., et al. (2024) A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy. Lab Chip 24 (13), 3252-3264.

  • Sept 12 (Hadano); Tudorica, D. A., et al. (2024) A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy. J. Cell Biol. 223 (7), e202309015.

  • Sept 5 (Shimakura); Masato, A., et al. (2024) Sequestosome-1 (SQSTM1/p62) as a target in dopamine catabolite-mediated cellular dyshomeostasis. Cell Death Dis. 15 (6), 424.

  • July 11 (Otomo); Silva, P., et al. (2024) Tumor-derived hypoxic small extracellular vesicles promote endothelial cell migration and tube formation via ALS2/Rab5/beta-catenin signaling. FASEB J. 38 (11), e23716.

  • June 27 (Shimakura); Ferrari, L., et al. (2024) Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusion. Sci. Adv. 10 (24), eadm8449.

  • June 6 (Hadano); Smith, D. M., et al. (2024) Rab30 facilitates lipid homeostasis during fasting. Nat. Commun. 15 (1), 4469.

  • May 23 (Murakami); Lecoq, P. E., et al. (2024) Influence of microgravity on spontaneous calcium activity of primary hippocampal neurons grown in microfluidic chips. NPJ Microgravity 10 (1), Pages 15.

  • May 16 (Shimakura); Barrow, E. R., et al. (2024) Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome. Cell Rep. 43 (3), Pages 113935.

  • Apr 25 (Otomo); Kodavati, M., et al. (2024) FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease. Nat. Commun. 15 (1), 2156.

  • Apr 18 (Hadano); Zhou, X., et al. (2024) Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons. Nat. Commun. 15 (1), 3113.
  • Feb 22　(Shimakura); Feng, X., et al. (2023) Local membrane source gathering by p62 body drives autophagosome formation. Nat. Commun. 14 (1), 7338.

  • Feb 15 (Otomo); Hickey, K. L., et al. (2023) Proteome census upon nutrient stress reveals Golgiphagy membrane receptors. Nature 623 (7985), 167-174.
  • Jan 11 (Hadano); Zhang, S., et al. (2023) C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy. Nat. Commun. 14 (1), 6360.

  • List of past JOURNAL CLUBs