JOURNAL CLUB

2025

  • July 3 (Wang); Zhu, D., et al. (2025) Pain-on-a-Chip: A microfluidic device for neuron differentiation and functional discrimination in animal models of chronic pain. Biosens. Bioelectron. 279, 117401.

  • June 26 (Shimakura); Chen, X. Q., et al. (2025) Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose. Alzheimers Dement. 21 (5), e70046.

  • June 19 (Hadano); Zhang, Z., et al. (2025) PTPsigma-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD. Neuron 113 (8), 1190-1205.

  • June 12 (Otomo); Li, A., et al. (2025) Endosomal protein DENND10 promotes developmental competence of neurite extension. iScience 28 (5), 112385.

  • May 29 (Mahvelati); Becerra, A. G., et al. (2022) Computing within bacteria: Programming of bacterial behavior by means of a plasmid encoding a perceptron neural network. Biosystems 213, 104608.

  • May 22 (Naoki); Strik, M, et al. (2025) Altered functional connectivity strength between structurally and functionally affected brain regions in visual snow syndrome. Brain Commun 7 (3), Pages fcaf171.

  • May 15 (Iwasaki); Liu, M, et al. (2024) Arched microfluidic channel for the promotion of axonal growth performance. iScience 27 (10), 110885.

  • May 8 (Yudahira); Fernandez Comaduran, F, et al. (2024) Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS. Cell Stress Chaperones 29 (3), 359-380.

  • May 1 (Wang); Wu, Z. Z., et al. (2006) Interfacing SH-SY5Y human neuroblastoma cells with SU-8 microstructures. Colloids Surf. B Biointerfaces 52 (1), 14-21.

  • Apr 17 (Shimakura); Trachsel-Moncho, L., et al. (2025) SNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics. J. Cell Biol. 224 (5), e202404009.

  • Feb 27 (Hadano); Handsaker, R. E., et al. (2025) Long somatic DNA-repeat expansion drives neurodegeneration in Huntington's disease. Cell 188 (3), 623-639.

  • Feb 13 (Shimakura); Hamamoto, K., et al. (2024) Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain. Cell Rep. 43 (12), 115016.

  • Feb 6 (Otomo); Smith, D. M., et al. (2024) Rab30 facilitates lipid homeostasis during fasting. Nat. Commun. 15 (1), 4469.

  • Jan 30 (Wang); Kim, K., et al. (2010) The optimization of PDMS-PMMA bonding process using silane primer. BioChip J. 4 (2), 148-154. / Borok, K., et al. (2021) PDMS Bonding Technologies for Microfluidic Applications: A Review. Biosensors (Basel) 11 (8), 292

  • Jan 16 (Hadano); De Decker, M., et al. (2024) C21ORF2 mutations point towards primary cilia dysfunction in amyotrophic lateral sclerosis. Brain awae331, https://doi.org/10.1093/brain/awae331.

  • Jan 9 (Shimakura); Noguchi, T., et al. (2023) LLPS of SQSTM1/p62 and NBR1 as outcomes of lysosomal stress response limits cancer cell metastasis. Proc. Natl. Acad. Sci.U.S.A. 120 (43), e2311282120.

    • 2024

  • Dec 26 (Otomo); Huilgol, D., et al. (2023) Direct and indirect neurogenesis generate a mosaic of distinct glutamatergic projection neuron types in cerebral cortex. Neuron 111 (16), 2557-2569.

  • Dec 19 (Wang); Ye, W., et al. (2020) 3D printing of gelatin methacrylate-based nerve guidance conduits with multiple channels. Mater. Des. 192, 108757.

  • Oct 31 (Murakami); Ogawa, T., et al. (2024) Formation and long-term culture of hiPSC-derived sensory nerve organoids using microfluidic devices. Bioengineering (Basel) 11 (8), 794.

  • Oct 17 (Hadano); Hutchings, A. J., et al. (2024) Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy. Nat. Commun. 15 (1), 8622.

  • Oct 10 (Shimakura); Cozzi, M., et al. (2024) Altered molecular and cellular mechanisms in KIF5A-associated neurodegenerative or neurodevelopmental disorders. Cell Death Dis. 15 (9), 692.

  • Sept 26 (Otomo); Scheiblich, H., et al. (2024) Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes. Neuron 112 (18), 3106-3125.e8.

  • Sept 19 (Murakami); Nebuloni, F., et al. (2024) A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy. Lab Chip 24 (13), 3252-3264.

  • Sept 12 (Hadano); Tudorica, D. A., et al. (2024) A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy. J. Cell Biol. 223 (7), e202309015.

  • Sept 5 (Shimakura); Masato, A., et al. (2024) Sequestosome-1 (SQSTM1/p62) as a target in dopamine catabolite-mediated cellular dyshomeostasis. Cell Death Dis. 15 (6), 424.

  • July 11 (Otomo); Silva, P., et al. (2024) Tumor-derived hypoxic small extracellular vesicles promote endothelial cell migration and tube formation via ALS2/Rab5/beta-catenin signaling. FASEB J. 38 (11), e23716.

  • June 27 (Shimakura); Ferrari, L., et al. (2024) Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusion. Sci. Adv. 10 (24), eadm8449.

  • June 6 (Hadano); Smith, D. M., et al. (2024) Rab30 facilitates lipid homeostasis during fasting. Nat. Commun. 15 (1), 4469.

  • May 23 (Murakami); Lecoq, P. E., et al. (2024) Influence of microgravity on spontaneous calcium activity of primary hippocampal neurons grown in microfluidic chips. NPJ Microgravity 10 (1), Pages 15.

  • May 16 (Shimakura); Barrow, E. R., et al. (2024) Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome. Cell Rep. 43 (3), Pages 113935.

  • Apr 25 (Otomo); Kodavati, M., et al. (2024) FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease. Nat. Commun. 15 (1), 2156.

  • Apr 18 (Hadano); Zhou, X., et al. (2024) Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons. Nat. Commun. 15 (1), 3113.
  • Feb 22　(Shimakura); Feng, X., et al. (2023) Local membrane source gathering by p62 body drives autophagosome formation. Nat. Commun. 14 (1), 7338.

  • Feb 15 (Otomo); Hickey, K. L., et al. (2023) Proteome census upon nutrient stress reveals Golgiphagy membrane receptors. Nature 623 (7985), 167-174.
  • Jan 11 (Hadano); Zhang, S., et al. (2023) C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy. Nat. Commun. 14 (1), 6360.

    • 2023

  • Nov 9 (Wang); Miny, Y., et al. (2022) Modeling neurodegenerative diseases using in vitro compartmentalized microfluidic devices. Front. Bioeng. Biotechnol. 10, 919646.

  • Oct 25 (Shimakura); Leboeuf, M., et al. (2023) ENGRAILED-1 transcription factor has a paracrine neurotrophic activity on adult spinal alpha-motoneurons. EMBO Rep. 24 (8), e56525.

  • Oct 18 (Otomo); Shelke, G. V., et al. (2023) Inhibition of endolysosome fusion increases exosome secretion. J. Cell Biol. 222 (6), e202209084.

  • Sept 28 (Hadano); Kallergi, E., et al. (2023) Profiling of purified autophagic vesicle degradome in the maturing and aging brain. Neuron 111 (15), 2329-2347 e7.

  • Sept 21 (Wang); Sorrentino, S., et al. (2022) Neurovascular signals in amyotrophic lateral sclerosis. Curr. Opin. Biotechnol. 74, 75-83.

  • Sept 7 (Shimakura); Seidel, M., et al. (2023) Propranolol reduces the accumulation of cytotoxic aggregates in C9orf72-ALS/FTD in vitro models. Curr. Res. Neurobiol. 5, 100105.

  • July 20 (Otomo); Gallagher, E. R. & and Holzbaur, E. L. F. (2023) The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy. Cell Rep. 42 (2), 11203.7

  • July 13 (Hadano); Jimenez-Moreno, N., et al. (2023) ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience. J. Cell Biol. 222 (5), e20230300.8

  • July 6 (Wang); Osaki, T., et al. (2018) Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons. Sci. Adv. 4 (10), eaat5847.

  • June 29 (Shimakura); Rovira, R., et al. (2022) The lysosomal proteome of senescent cells contributes to the senescence secretome. Aging Cell 21 (10), e13707.

  • June 22 (Otomo); Schuhmacher, J. S., et al. (2023) The Rab5 effector FERRY links early endosomes with mRNA localization. Mol. Cell 83 (11), 1839-1855 e13.

  • June 15 (Hadano); Kurusu, R., et al. (2023) Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex. Dev. Cell 58, in press; DOI: 10.1016/j.devcel.2023.04.015.

  • June 8 (Wang); Marshall, K. L., et al. (2023) Enhanced axonal regeneration of ALS patient iPSC-derived motor neurons harboring SOD1(A4V) mutation. Sci. Rep. 13 (1), Pages 5597.

  • June 1 (Shimakura); Croft, C. L., et al. (2022) Optical pulse labeling studies reveal exogenous seeding slows alpha-synuclein clearance. NPJ Parkinsons Dis. 8 (1), Pages 173.

  • May 18 (Otomo); Neel, D. V., et al. (2023) Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration. Neuron 111 (8), 1222-1240 e9.

  • May 10 (Hadano); Baughn, M. W., et al. (2023) Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies. Science 379 (6637), 1140-1149.

  • Apr 20 (Wang); Park, J., et al. (2014) A microchip for quantitative analysis of CNS axon growth under localized biomolecular treatments. J. Neurosci. Methods 221, 166-174.

  • Apr 13 (Shimakura); Xia, Q., et al. (2023) Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy. Cell Biosci. 13 (1), Page 37.

  • Mar 30 (Otomo); Coelho, P. P., et al. (2022) Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation. Nat. Commun. 13 (1), Page 3812.
  • Mar 9 (Murakami); Stoklund Dittlau, K., et al. (2023) FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms. Mol. Neurodegener. 18 (1), Page 5.

  • Mar 2 (Hadano); Hung, S. T., et al. (2023) PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. Cell 186 (4), 786–802.e28.

  • Feb 9 (Yamaguchi); Morizawa, Y. M., et al. (2022) Synaptic pruning through glial synapse engulfment upon motor learning. Nat. Neurosci. 25 (11), 1458-1469.

  • Feb 2 (Yudahira); Stoklund Dittlau, K., et al. (2021) Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition. Stem Cell Rep. 16 (9), 2213-2227.

  • Jan 12 (Shimakura); Shimobayashi, S. F. & Ohsaki, Y. (2019) Universal phase behaviors of intracellular lipid droplets. Proc. Natl. Acad. Sci. U.S.A. 116 (51), 25440-25445.

  • List of past JOURNAL CLUBs