List of past JOURNAL CLUBs: ~2020
2022
Dec 22 (Otomo); Kulkarni, V. V., et al. (2022) Retrograde axonal autophagy and endocytic pathways are parallel and separate in neurons. J. Neurosci. 42 (45), 8524-8541.
Nov 10 (Murakami); Ristola, M., et al. (2021) Directional growth of human neuronal axons in a microfluidic device with nanotopography on azobenzene‐based material. Adv. Mater. Interfaces 8 (11), 2100048.
Oct 17 (Hadano); Shao, W., et al. (2022) Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration. Science 378 (6615), 94-99.
Oct 11 (Yudahira); Badu-Mensah, A., et al. (2020) Functional skeletal muscle model derived from SOD1-mutant ALS patient iPSCs recapitulates hallmarks of disease progression. Sci. Rep. 10 (1), 14302.
Sept 29 (Yamaguchi); Kase, Y., et al. (2022) The GADD45G/p38 MAPK/CDC25B signaling pathway enhances neurite outgrowth by promoting microtubule polymerization. iScience 25 (4), 104089.
Sept 15 (Shimakura); Tonnesen, J., et al. (2018) Super-resolution imaging of the extracellular space in living brain tissue. Cell 172 (5), 1108-1121 e15.
Sept 8 (Otomo); Hatoyama, Y., et al. (2021) Establishment and analysis of conditional Rab1- and Rab5-knockout cells using the auxin-inducible degron system. J. Cell Sci. 134 (24), jcs.259184.
July 28 (Murakami); Hakli, M., et al. (2022) Human neurons form axon-mediated functional connections with human cardiomyocytes in compartmentalized microfluidic chip. Int. J. Mol. Sci. 23 (6), 3148.
July 21 (Hadano); Hooper, K. M., et al. (2022) V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy. J. Cell Biol. 221 (6), e202105112.
July 14 (Yamaguchi); Goto, A., et al. (2021) Stepwise synaptic plasticity events drive the early phase of memory consolidation. Science 374 (6569), 857-863.
June 23 (Yudahira); Stein, J., et al. (2021) Increased ROS-dependent fission of mitochondria causes abnormal morphology of the cell powerhouses in a murine model of amyotrophic lateral sclerosiss. Oxid. Med. Cell Longev. 2021, 6924251.
June 16 (Shimakura); Lee, J. H., et al. (2022) Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Abeta in neurons, yielding senile plaques. Nat. Neurosci. 25 (6), 688-701.
June 9 (Otomo); Lin, H. C., et al. (2021) NGN2 induces diverse neuron types from human pluripotency. Stem Cell Rep. 16 (9), 2118-2127.
June 2 (Murakami); Yamamoto, K., et al. (2021) Development of a human neuromuscular tissue-on-a-chip model on a 24-well-plate-format compartmentalized microfluidic device. Lab Chip 21 (10), 1897-1907.
May 26 (Hadano); Lie, P. P. Y., et al. (2022) Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca(2+) efflux and disrupted by PSEN1 loss of function. Sci. Adv. 8 (17), eabj5716.
May 12 (Okada-Yamaguchi); Kamath, T., et al. (2022) Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease. Nat. Neurosci. 25 (5), 588-595.
Apr 21 (Yudahira); Mietto, B. S., et al. (2021) Schwann cells provide iron to axonal mitochondria and its role in nerve regeneration. J. Neurosci. 41 (34), 7300-7313.
Apr 14 (Shimakura); Sun, R., et al. (2018) Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation. Cell Res. 28 (4), 405-415.
Mar 31 (Otomo); Garcia-Morales, V., et al. (2019) Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1. Nat. Commun. 10 (1), 3784.
Mar 10 (Okada); Yang, S., et al. (2022) Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9. Neuron 110 (5), 824-840.e10.
Mar 3 (Yudahira); Salam, S., et al. (2021) Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations. Sci. Rep. 11 (1), 13613.
Feb 24 (Naitou); Lin, C. Y., et al. (2020) In vitro neuromuscular junction induced from human induced pluripotent stem cells. J. Vis. Exp. 166, e61396.
Jan 27 (Shimakura); Wu, K. K. L., et al. (2021) The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages. Nat. Commun. 12 (1), 6637.
Jan 6 (Hadano); Chamberlain, K. A., et al. (2021) Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2. Neuron 109 (21), 3456-3472.e8.
2021
Dec 23 (Otomo); Pereira, J. D., et al. (2021) Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions. Nat. Commun. 12 (1), 4744.
Dec 9 (Yudahira); Singh, V., et al. (2020) The TLK1/Nek1 axis contributes to mitochondrial integrity and apoptosis prevention via phosphorylation of VDAC1. Cell Cycle 19 (3), 363-375.
Dec 2 (Naitou); Pezinski, M., et al. (2020) An improved method for culturing myotubes on laminins for the robust clustering of postsynaptic machinery. Sci. Rep. 10 (1), 4524.
Nov 25 (Muramatsu); Sala-Jarque, J., et al. (2020) Neuromuscular activity induces paracrine signaling and triggers axonal regrowth after injury in microfluidic Lab-On-Chip devices. Cells 9 (2), 302.
Nov 11 (Shimakura); Nunes, Q. M., et al. (2019) The heparin-binding proteome in normal pancreas and murine experimental acute pancreatitis. PLoS One 14 (6), e0217633.
Nov 4 (Hadano); Bowles. K. R., et al. (2021) ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids. Cell 184 (17), 4547-4563.e17.
Oct 28 (Otomo); B. I. C. C. Network (2021) A multimodal cell census and atlas of the mammalian primary motor cortex. Nature 598 (7879), 86-102.
Oct 14 (Yudahira); Fang, X., et al. (2015) The NEK1 interactor, C21ORF2, is required for efficient DNA damage repair. Acta Biochim. Biophys. Sin. 47 (10), 834-841.
Oct 7 (Naitou); Lin, C. Y., et al. (2019) iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases. JCI Insight 4 (18), e124299.
Sept 30 (Muramatsu); Uzel, S. G., et al. (2016) Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units. Sci. Adv. 2 (8), e1501429.
Sept 16 (Shimakura); Ochieng, J., et al. (2018) Extracellular histones are the ligands for the uptake of exosomes and hydroxyapatite-nanoparticles by tumor cells via syndecan-4. FEBS Lett. 592 (19), 3274-3285.
Sept 9 (Hadano); Nieto-Torres, J. L., et al. (2021) LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes. Curr. Biol. 31 (15), 3440-3449.e7.
July 15 (Otomo); Park, Y., et al. (2021) Three-dimensional, multifunctional neural interfaces for cortical spheroids and engineered assembloids. Sci. Adv. 7, eabf9153.
July 1 (Naitou); Saini, J., et al. (2019) Simplified in vitro engineering of neuromuscular junctions between rat embryonic motoneurons and immortalized human skeletal muscle cells. Stem Cells Cloning 12, 1-9.
June 17 (Muramatsu); Kawada, J., et al. (2017) Generation of a motor nerve organoid with human stem cell-derived neurons. Stem Cell Rep. 9 (5), 1441-1449.
June 10 (Shimakura); Mattinzoli, D., et al. (2016) FGF23-regulated production of Fetuin-A (AHSG) in osteocytes. Bone 83, 35-47.
June 3 (Hadano); Su, H., et al. (2021) Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. Cancer Cell 39 (5), 678-693.e11.
May 27 (Otomo); Pensalfini, A., et al. (2020) Endosomal dysfunction induced by directly overactivating Rab5 recapitulates prodromal and neurodegenerative features of Alzheimer's disease. Cell Rep. 33 (8), 108420.
May 20 (Sato); Li, Z., et al. (2020) Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD. Proc. Natl. Acad. Sci. U. S. A. 117 (49), 25104-25115.
May 13 (Naitou); Shahini, A., et al. (2018) Efficient and high yield isolation of myoblasts from skeletal muscle. Stem Cell Res. 30, 122-129.
May 6 (Ikeda); Aydin, O., et al. (2020) Development of 3D neuromuscular bioactuators. APL Bioeng. 4 (1), 016107.
April 22 (Muramatsu); Yamaoka, N., et al. (2019) Open-chamber co-culture microdevices for single-cell analysis of skeletal muscle myotubes and motor neurons with neuromuscular junctions. BioChip J. 13 (2), 127-132.
April 15 (Shimakura); Han, D., et al. (2018) Plasma Hemopexin ameliorates murine spinal cord injury by switching microglia from the M1 state to the M2 state. Cell Death Dis. 9 (2), 181.
April 8 (Hadano); Kim, J., et al. (2021) ALS2 regulates endosomal trafficking, postsynaptic development, and neuronal survival. J. Cell Biol. 220 (5), e202007112.
April 1 (Otomo); Rivas, S., et al. (2020) The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells. Sci. Rep. 10 (1), 22302.
March 25 (Yudahira); Zuo, X., et al. (2012) TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS. Nat. Struct. Mol. Biol. 28 (2), 132-142.
March 18 (Shimakura); Pal, D., et al. (2012) Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat. Med. 18 (8), 1279-1285.
March 11 (Sato); Kwon, O. S., et al. (2021) Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis. Nat. Commun. 12 (1), 1351.
March 4 (Otomo); Hyung, S., et al. (2021) A 3D disease and regeneration model of peripheral nervous system-on-a-chip. Sci. Adv. 7 (5), eabd9749.
February 25 (Hadano); Chiot, A., et al. (2020) Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival. Nat. Neurosci. 23 (11), 1339-1351.
February 4 (Mitsui); Farrawell, N. E., et al. (2020) Ubiquitin homeostasis is disrupted in TDP-43 and FUS cell models of ALS. iScience 23 (11), 101700.
January 28 (Fujita); Gladkov, A., et al. (2017) Design of cultured neuron networks in vitro with predefined connectivity using asymmetric microfluidic channels. Sci. Rep. 7 (1), 15625.
January 7 (Shimakura); Wegmann, S., et al. (2018) Tau protein liquid-liquid phase separation can initiate tau aggregation. EMBO J. 37 (7), e98049.
2020
December 24 (Sato); Watanabe, Y., et al. (2020) An amyotrophic lateral sclerosis-associated mutant of C21ORF2 is stabilized by NEK1-mediated hyperphosphorylation and the inability to bind FBXO3. iScience 23 (9), 101491.
December 10 (Otomo); Fellows, A. D., et al. (2020) IGF1R regulates retrograde axonal transport of signalling endosomes in motor neurons. EMBO Rep. 21 (3), e49129.
December 3 (Hadano); Yu, C. H., et al. (2020) TDP-43 triggers mitochondrial DNA release via mPTP to activate cGAS/STING in ALS. Cell 183 (3), 636-649.e18.
November 12 (Kano); Shimizu, K., et al. (2015) Microfluidic devices for construction of contractile skeletal muscle microtissues. J. Biosci. Bioeng. 119 (2), 212-216.
November 5 (Mitsui); Fang, C., et al. (2020) SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation. Autophagy, in press.
October 29 (Fujita); Majumdar, D., et al. (2011) Co-culture of neurons and glia in a novel microfluidic platform. J. Neurosci. Methods 196 (1), 38-44.
October 22 (Otomo); Lopez-Hernandez, T., et al. (2020) Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis. Nat. Cell Biol. 22 (7), 815-827.
October 8 (Sato); Oguchi, M. E., et al. (2020) A comprehensive analysis of Rab GTPases reveals a role for Rab34 in serum starvation-induced primary ciliogenesis. J. Biol. Chem. 295 (36), 12674-12685.
October 1 (Shimakura); Liu, Z., et al. (2020) LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes. EMBO J., e104862.
September 24 (Hadano); Yamano, K., et al. (2020) Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy. J. Cell Biol. 219 (9), e201912144.
September 17 (Mitsui); Fischer, K., et al. (2020) The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation. Nat. Commun. 11 (1), 2306.
September 10 (Otomo); Gallotta, I., et al. (2020) Extracellular proteostasis prevents aggregation during pathogenic attack. Nature 584 (7821), 410-414.
September 3 (Sato); Matsumoto, M., et al. (2019) Dynamic changes in ultrastructure of the primary cilium in migrating neuroblasts in the postnatal brain. J. Neurosci. 39 (50), 9967-9988.
July 16 (Shimakura); Ravera, S., et al. (2019) Altered glucose catabolism in the presynaptic and perisynaptic compartments of SOD1(G93A) mouse spinal cord and motor cortex indicates that mitochondria are the site of bioenergetic imbalance in ALS. J. Neurochem. 151 (3), 336-350.
July 9 (Ono); Levic, D. S., et al. (2020) Distinct roles for luminal acidification in apical protein sorting and trafficking in zebrafish. J. Cell Biol. 219 (4), in press.
July 2 (Hadano); Khobrekar, N. V., et al. (2020) The dynein adaptor RILP controls neuronal autophagosome biogenesis, transport, and clearance. Dev. Cell 53 (2), 141-153 e4.
June 25 (Mitsui); Gerbino, V., et al. (2020) The loss of TBK1 kinase activity in motor neurons or in all cell types differentially impacts ALS disease progression in SOD1 mice. Neuron 106 (5), 789-805 e5.
June 18 (Otomo); Wang, T. S., et al. (2020) Endolysosomal targeting of mitochondria is integral to BAX-mediated mitochondrial permeabilization during apoptosis signaling. Dev. Cell 53, in press.
June 11 (Shimakura); Romano, R., et al. (2020) Alteration of the late endocytic pathway in Charcot-Marie-Tooth type 2B disease. Cell. Mol. Life Sci., in press.
June 4 (Sato); Bae, J. E., et al. (2019) Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model. Cell Death Dis. 10 (12), 952.
May 28 (Ono); Kamentseva, R., et al. (2020) Functional cycle of EEA1-positive early endosome: Direct evidence for pre-existing compartment of degradative pathway. PLoS One 15 (5), e0232532.
May 21 (Hadano); Laiouar, S., et al. (2020) RabX1 organizes a late endosomal compartment that forms tubular connections to lysosomes consistent with a "Kiss and Run" mechanism. Curr. Biol. 30 (7), 1177-1188.e5.
May 14 (Mitsui); Jenkins, E. C., et al. (2020) Proteasome mapping reveals sexual dimorphism in tissue-specific sensitivity to protein aggregations. EMBO Rep. 21 (4), e48978.
May 7 (Otomo); Cong, X. X., et al. (2020) Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and myoblast differentiation during muscle regeneration. Cell Death Differ., in press.
April 2 (Shimakura); Liu, G., et al. (2020) Cdc48/VCP and endocytosis regulate TDP-43 and FUS toxicity and turnover. Mol. Cell. Biol., 40 (4), e00256-19.
March 26 (Sato); Ott, C., et al. (2018) VPS4 is a dynamic component of the centrosome that regulates centrosome localization of gamma-tubulin, centriolar satellite stability and ciliogenesis. Sci. Rep., 8 (1), 3353.
March 19 (Ono); Sun, M., et al. (2020) Control of Rab7a activity and localization through endosomal type Igamma PIP 5-kinase is required for endosome maturation and lysosome function. FASEB J., 34 (2), 2730-2748.
March 12 (Hadano); Han, Q., et al. (2020) Restoring cellular energetics promotes axonal regeneration and functional recovery after spinal cord injury. Cell Metab., 31 (3), 623-641.
March 5 (Mitsui); Sanchez-Martin, P., et al. (2020) NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system. EMBO Rep., e48902.
February 20 (Otomo); Nagano, M., et al. (2019) Rab5-mediated endosome formation is regulated at the trans-Golgi network. Commun. Biol. 2, 419.
February 13 (Shimakura); Farhan, S. M. K., et al. (2019) Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nat. Neurosci. 22, 1966-1974.
January 30 (Sato); Monis, W. J., et al. (2016) BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia. J. Cell Biol. 216 (7), 2131-2150.
January 16 (Ono); D'Souza, Z., et al. (2019) Defects in COG-mediated Golgi trafficking alter endo-lysosomal system in human cells. Front. Cell Dev. Biol. 7, 118.
January 9 (Hadano); Toh, H., et al. (2019) Group A Streptococcus modulates RAB1- and PIK3C3 complex-dependent autophagy. Autophagy, in press; 10.1080/15548627.2019.1628539
2019
December 19 (Otomo); Ramirez, C., et al. (2019) Plasma membrane V-ATPase controls oncogenic RAS-induced macropinocytosis. Nature 576 (7787), 477-481.
November 28 (Mitsui); Han, C., et al. (2019) Exosomes from patients with Parkinson's disease are pathological in mice. J. Mol. Med. 97 (9), 1329-1344.
November 21 (Shimakura); Vandoorne, T., et al. (2019) Differentiation but not ALS mutations in FUS rewires motor neuron metabolism. Nat. Commun. 10 (1), 4147.
November 14 (Sato); Zuo, X., et al. (2019) Primary cilia and the exocyst are linked to urinary extracellular vesicle production and content. J. Biol. Chem., in press.
November 7 (Ono); Etoh, K. & Fukuda, M. (2019) Rab10 regulates tubular endosome formation through KIF13A and KIF13B motors. J. Cell Sci. 132 (5), jcs226977. doi:10.1242/jcs.226977.
October 31 (Hadano); Joshi, A.U., et al. (2019) Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration. Nat. Neurosci. 22 (10), 1635-1648.
October 10 (Otomo); Fraser, J., et al. (2019) Targeting of early endosomes by autophagy facilitates EGFR recycling and signalling. EMBO Rep. 20 (10), e47734.
October 3 (Mitsui); Deng, Z., et al. (2019) ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway. Autophagy, in press.
September 26 (Shimakura); Giampetruzzi, A., et al. (2019) Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis. Nat Commun 10 (1), 3827.
September 12 (Sato); Kukic, I., et al. (2016) The IN/OUT assay: a new tool to study ciliogenesis. Cilia 5, 23.
September 5 (Ono); Sato, R., et al. (2019) Apical trafficking pathway of influenza A virus HA and NA via Rab17- and Rab23-positive compartments. Front. Microbiol. 2019 Aug 13;10:1857.
July 19 (Hadano); Baba, T., et al. (2019) Phosphatidylinositol 4,5-bisphosphate controls Rab7 and PLEKHM1 membrane cycling during autophagosome-lysosome fusion. EMBO J. 38 (8), e100312.
July 11 (Otomo); Cui, Y., et al. (2019) Retromer has a selective function in cargo sorting via endosome transport carriers. J. Cell Biol. 218 (2), 615-631.
July 4 (Mitsui); Medinas, D. B., et al. (2018) Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U.S.A. 115 (32), 8209-8214.
June 27 (Sato); Scheidel, N., et al. (2018) Endosome maturation factors Rabenosyn-5/VPS45 and caveolin-1 reglate ciliary membrane and polycystin-2 homeostasis. EMBO J. 37, e98248.
June 20 (Ono); Tao, T., et al. (2019) Golgi-resident TRIO regulates membrane trafficking during neurite outgrowth. J. Biol. Chem. in press.
June 13 (Hadano); Nakamura, S., et al. (2019) Suppression of autophagic activity by Rubicon is a signature of aging. Nat. Commun. 10, 847.
June 6 (Otomo); Seaman, M.N.J., et al. (2018) Ihibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex. J. Cell Sci. 131 (12).
May 30 (Mitsui); Lu, J., et al. (2019) L3MBTL1 regulates ALS/FTD-associated proteotoxicity and quality control. Nat. Neurosci. 22, 875-886.
May 23 (Sato); Kasahara, K., et al. (2014) Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension. Nat. Commun. 5, 5081.
May 16 (Ono); Rivero-Rios, P., et al. (2019) The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A. J. Biol. Chem. 294, 4738-4758.
May 9 (Hadano); Lafont, E., et al. (2018) TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation. Nat. Cell Biol. 20, 1389-1399.
April 25 (Otomo); Kuchitsu, Y., et al. (2018) Rab7 knockout unveils regulated autolysosome maturation induced by glutamine starvation. J. Cell Sci. 131, doi: 10.1242/jcs.215442.
April 18 (Mitsui); Takahashi, M., et al. (2018) USP10 is a driver of ubiquitinated protein aggregation and aggresome formation to inhibit apoptosis. iScience 9, 433-450.
April 11 (Sato); Roy, K., et al. (2017) Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation. J. Biol. Chem. 292, 17703-17717.
April 4 (Ono); Moya-Alvarado, G., et al. (2018) Brain-derived neurotrophic factor (BDNF) regulates Rab5-positive early endosomes in Hippocampal neurons to induce dendritic branching. Front. Cell Neurosci. 12, 493.
March 28 (Otomo); Cioni, J. -M., et al. (2019) Late endosomes act as mRNA translation platforms and sustain mitochondria in axons. Cell 176, 56-72.
March 14 (Ishiyama); Ono, K., et al. (2017) Oligodendrocyte precursor cells in the mouse optic nerve originate in the preoptic area. Brain Struct. Funct. 222, 2441-2448.
March 7 (Hadano); Vogler, T.O., et al. (2018) TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle. Nature 563, 508-513.
February 28 (Shimakura); Sato, K., et al. (2018) Altered oligomeric states in pathogenic ALS2 variants associated with juvenile motor neuron diseases cause loss of ALS2-mediated endosomal function. J. Biol. Chem. 293 (44), 17135-17153.
February 21 (Mitsui); Noguchi, T., et al. (2018) Nuclear-accumulated SQSTM1/p62-based ALIS act as microdomains sensing cellular stresses and triggering oxidative stress-induced parthanatos. Cell Death Dis. 9, 1193.
January 31 (Sato); Yoshimura, S., et al. (2007) Functional dissection of Rab GTPases involved in primary cilium formation. J. Cell Biol. 178, 363-369.
January 10 (Ono); Striz, A.C., et al. (2018) Rab17 apical delivery of hepatic transcytotic vesicles. Mol. Biol. Cell 29, 2887-2897.
2018
December 20 (Ishiyama); Kageyama, S., et al. (2018) Negative regulation of the Keap1-Nrf2 pathway by a p62/Sqstm1 splicing variant. Mol. Cell. Biol. 38, e00642-17.
November 22 (Otomo); Tsuchiya, M., et al. (2018) p62/SQSTM1 promotes rapid ubiquitin conjugation to target proteins after endosome rupture during xenophagy. FEBS Open Bio 8, 470-480.
November 15 (Hadano); Benkler, C., et al. (2018) Aggregated SOD1 causes selective death of cultured human motor neurons. Sci. Rep. in press.
November 8 (Shimakura); Kunita, R., et al. (2004) Homo-oligomerization of ALS2 through its unique carboxy-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking. J. Biol. Chem. 279, 38626-38635.
October 25 (Mitsui); Lee, J., et al. (2018) Secretion of misfolded cytosolic proteins from mammalian cells is independent of chaperone-mediated autophagy. J. Biol. Chem. 293, 14359-14370.
October 18 (Kushida); Osaki, T., et al. (2018) Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons. Sci. Adv. 4, eaat5847.
October 4 (Sato); Nokes, R., et al. (2008) Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells. J. Cell Biol.
September 27 (Ono); Puri, C., et al. (2018) The RAB11A-positive compartment is a primary platform for autophagosome assembly mediated by WIPI2 recognition of PI3P-RAB11A. Dev. Cell 45, 114-131.
September 20 (Ishiyama); Hadano, S. et al. (2016) Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice. Hum. Mol. Genet. 25, 3321-3340.
September 6 (Otomo); Mejlvang, J., et al. (2018) Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy. J. Cell Biol. in press.
July 26 (Hadano); Chitiprolu, M., et al. (2018) A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy. Nat. Commun., in press.
July 19 (Otomo); Fernández, Á. F., et al. (2018) Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice. Nature 558, 136-140.
July 12 (Mitsui); Matsumoto, G., et al. (2018) N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression. Sci. Rep. 8, 9585.
July 5 (Kushida); Li, W., et al. (2017) Investigation of the subcellular neurotoxicity of amyloid-β using a device integrating microfluidic perfusion and chemotactic guidance. Adv. Healthcare Mater. 6, 1600895.
June 28 (Sato); Arellano, J. I., et al.（2012）Development and distribution of neuronal cilia in mouse neocortex. J. Comp. Neurol. 520, 848-873.
June 21 (Ono); Liu, Z., et al. (2018) LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network. Hum. Mol. Genet. 27, 385-395.
June 14 (Otomo); Ye, M., et al. (2018) Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling. eLife 7, e33012.
June 7 (Hadano); Matsui, T., et al. (2018) Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17. J. Cell Biol. in press.
May 31 (Mitsui); Rudnick, N.D., et al. (2017) Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS. Proc. Natl. Acad. Sci., U.S.A., in press.
May 24 (Kushida); Kim, H. S., et al. (2016) A Microchip for high-throughput axon growth drug screening. Micoromachines 7, 114.
May 17 (Sato); Taschner, M. et al. (2018) Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis. eLife, in press
April 26 (Ono); Steger, M., et al. (2016) Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases. elife 5, e12813.
April 19 (Otomo); Oguchi, M. E., et al. (2018) Rab20, a novel Rab small GTPase that negatively regulates neurite outgrowth of PC12 cells. Neurosci. Lett. 662, 324-330.
April 12 (Hadano); Sha, Z. et al. (2018) Rapid induction of p62 and GAB ARA PL1 upon proteasome inhibition promotes survival before autophagy activation. J. Cell Biol., in press
March 29 (Mitsui); Sun, D., et al. (2017) Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation. Cell Res., in press.
March 22 (Kushida); Bhattacharjee, N. and Folch, A. (2017) Large-scale microfluidic gradient arrays reveal axon guidance behaviors in hippocampal neurons. Microsys. Nanoengine. 3, 17003.
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