PUBLICATIONS

2024

  1. Hadano, S. (2024) Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and frontotemporal dementia. (JP) Dementia Japan 38 (1), 140-147.
  2. Motosugi, N., Sugiyama, A., Otomo, A., Sakata, Y., Araki, T., Hadano, S., Kumasaka, N., and Fukuda, A. (2024) Effect of PCDH19 missense mutation on cell-to-cell proximity and neuronal development under heterotypic condition. PNAS nexus 3 (3), pgae060.
  3. Oka, A., Hadano, S., Ueda, M. T., Nakagawa, S., Komaki, G., and Ando, T. (2024) Rare CRHR2 and GRM8 variants identified as candidate factors associated with eating disorders in Japanese patients by whole exome sequencing. Heliyon 10 (8), e28643.
  4. Rossi Sebastiano, M., Hadano, S., Cesca, F., IAHSP Consortium, and Ermondi, G. (2024) Preclinical alternative drug discovery programs for monogenic rare diseases. Should small molecules or gene therapy be used? The case of hereditary spastic paraplegias. Drug Discov. Today29 (10), 104138.
  5. Hadano, S. (2024) Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and frontotemporal dementia. (JP) Neurology 101 (2), 150-157.

2023

  1. Sato, K., Suzuki-Utsunomiya, K., Mitsui, S., Ono, S., Shimakura, K., Otomo, A., and Hadano, S. (2023) Central nervous system specific high molecular weight ALS2/alsin homophilic complex is enriched in mouse brain synaptosomes. Biochem. Biophys. Res. Commn. 638, 168-175.
  2. Jiang, Q., Lin, J., Wei, Q., Li, C., Hou, Y., Zhang, L., Ou, R., Liu, K., Yang, T., Xiao, Y., Hadano, S., and Shang, H. -F. (2023) Genetic and clinical characteristics of ALS patients with NEK1 gene variants. Neurobiol. Aging 123, 191-199.
  3. Serizawa, S. and Hadano, S. (2022) Impact of COVID-19 infection on clinical care: Insights from interviews with multidisciplinary healthcare professionals involved in amyotrophic lateral sclerosis patients. (JP) The Japanese Society of Medical Networking for Intractable Diseases 10 (2), 75-88.

2022

  1. Otomo, A., Ono, S., Sato, K., Mitsui, S. Shimakura, K., Kimura, H., and Hadano, S. (2022) High-throughput quantitative analysis of axonal transport in cultured neurons from SOD1H46R ALS mice by using a microfluidic device. Neurosci. Res. 174, 46-52.
  2. Rossi Sebastiano, M., Ermondi, G., Hadano, S., and Caron, G. (2022) AI-based protein structure databases have the potential to accelerate rare diseases research: AlphaFoldDB and the case of IAHSP/Alsin. Drug Discov. Today 27 (6), 1652-1660.
  3. Mitsui, S., Otomo, A., Sato, K., Ishiyama, M., Shimakura, K., Okada-Yamaguchi, C., Warabi, E., Yanagawa, T., Aoki, M., Shang, H. -F., and Hadano, S. (2022) SQSTM1, a protective factor of SOD1-linked motor neuron disease, regulates the accumulation and distribution of ubiquitinated protein aggregates. Neurochem. Int. 158, 105364.
  4. Otomo, A. and Hadano, S. (2022) 1. Degradation mechanisms of cells. Autophagy Dysfunction in Alzheimer's Disease and Dementia (Edited by Hamano, T. & Mutoh,T.), ELSEVIER/Academic Press, San Diego/California, U.S.A., pp3-21.
  5. Rossi Sebastiano, M., Ermondi, G., Sato, K., Otomo, A., Hadano, S., and Caron, G. (2022) Personalized treatment for Infantile Ascending Hereditary Spastic Paralysis based on in silico strategies. Molecules 27 (20), 7063.
  6. Motosugi, N., Sugiyama, A., Okada, C., Otomo, A., Umezawa, A., Akutsu, H, Hadano, S., and Fukuda, A. (2022) De-erosion of X-chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in human pluripotent stem cells. Cell Rep. Methods　2 (12), 100352.

2021

  1. Nozaki, M., Otomo, A., Mitsui, S., Ono, S., Shirakawa, R., Chen, Y. P., Hama, Y., Sato, K., Chen, X. P., Suzuki, T., Shang, H. -F., and Hadano, S. (2021) SQSTM1L341V variant that is linked to sporadic ALS exhibits impaired association with MAP1LC3 in cultured cells. eNeurologicalSci 22, 100301.
  2. Klionsky, D. J. et al , (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17 (1), 1-382.
  3. Shimakura, K., Sato, K., Mitsui, S., Ono, S., Otomo, A., and Hadano, S. (2021) The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2. Biochem. Biophys. Res. Commn. 569 (10), 106-111.

2020

  1. Ono, S., Otomo, A., Murakoshi, S., Mitsui, S., Sato, K., Fukuda, M., and Hadano, S. (2020) ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes. Biochem. Biophys. Res. Commn. 523 (4), 908-915.
  2. Hadano, S. (2020) Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and frontotemporal dementia. (JP) Igaku no Ayumi 272 (9), 885-891.
  3. Fujitani, K., Otomo, A., Nagayama, Y., Tachibana, T., Kato, R., Kawashima, Y., Kodera, Y., Kato, T., Takada, S., Tamura, K., Takamatsu, N., and Ito, M. (2020) PACT/PRKRA and p53 regulate transcriptional activity of DMRT1. Genet. Mol. Biol. 43 (2), e20190017.
  4. Kashiwagi, H., Ishimoto, H., Izumi, S., Seki, T., Kinami, R., Otomo, A., Takahashi, K., Kametani, F., Hirayama, N., Sasaki, E., Shiina, T., Sakabe, K., Mikami, M., and Kametani, Y. (2020) Human PZP and common marmoset A2ML1 as pregnancy related proteins. Sci. Rep. 10 (1), 5088.
  5. Otomo, A., Ueda, M. T., Fujie, T., Hasebe, A., Suematsu, Y., Okamura, Y., Takeoka, S., Hadano, S., and Nakagawa, S. (2020) Efficient differentiation and polarization of primary cutured neurons on poly(lactic acid) scaffolds with microgrooved structures. Sci. Rep. 10 (1), 6716.
  6. Hayashi, H., Wang, T., Tanaka, M., Ogiwara, S., Okada, C., Ito, M., Fukunishi, N., Iida, Y., Nakamura, A., Sasaki, A., Amano, S., Yoshida, K., Otomo, A., Ohtsuka, M., and Hadano, S. (2020) Monitoring the autophagy-endolysosomal system using monomeric Keima-fused MAP1LC3B. PLoS ONE 15 (6), e0234180.
  7. Oka, A., Takagi, A., Komiyama, E., Yoshihara, N., Mano, S., Hosomichi, K., Suzuki, S., Haida, Y., Motosugi, N., Hatanaka, T., Kimura, M., Ueda, M. T., Nakagawa, S., Miura, H., Ohtsuka, M., Tanaka, M., Komiyama, T., Otomo, A., Hadano, S., Mabuchi, T., Beck, S., Inoko, H., and Ikeda, S. (2020) Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss. EBioMedicine 57, 102810.

2019

  1. Yokoyama, S., Otomo, A., Hadano, S., and Kimura, H. (2019) An open-type microdevice to improve the quality of fluorescence labeling for axonal transport analysis in neurons. Biomicrofluidics 13 (3), 034104.

2018

  1. Sato, K., Otomo, A., Ueda, M. T., Hiratsuka, Y., Suzuki-Utsunomiya, K., Sugiyama, J., Murakoshi, S., Mitsui, S., Ono, S., Nakagawa, S., Shang, H. -F., and Hadano, S. (2018) Altered oligomeric states in pathogenic ALS2 variants associated with juvenile motor neuron diseases cause loss of ALS2-mediated endosomal function. J. Biol. Chem. 293 (44), 17135-17153.
  2. Fujimori, K., Ishikawa, M., Otomo, A., Atsuta, N., Nakamura, R., Akiyama, T., Hadano, S., Aoki, M., Saya, H., Sobue, G., and Okano, H. (2018) Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent. Nat. Med. 24 (10), 1579-1589.
  3. Mitsui, S., Otomo, A., Nozaki, M., Ono, S., Sato, K., Shirakawa, R., Adachi, H., Aoki, M., Sobue, G., Shang, H. -F., and Hadano, S. (2018) Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model. Mol. Brain 11 (1), 30.
  4. Imaizumi, K., Fujimori, K., Ishii, S., Otomo, A., Hosoi, Y., Miyajima, H., Warita, H., Aoki, M., Hadano, S., Akamatsu, W., and Okano, H. (2018) Rostrocaudal areal patterning of human PSC-derived cortical neurons by FGF8 signaling. eNeuro 5 (2), e0368-17.2018 1–9.

2017

  1. Kanno, T., Yasutake, K., Tanaka, K., Hadano, S., and Ikeda, J. -E. (2017) A novel function of N-linked glycoproteins, alpha-2-HS-glycoprotein and hemopexin: Implications for small molecule compound-mediated neuroprotection. PLoS ONE 12 (10), e0186227.
  2. Inoue, Y., Otomo, A., Takahashi, K., Moriya, H., Ohnuki, Y., Taniguchi, Y., Izumi, S., and Hadano, S. (2017) Development of the practical studies for learning and understanding genes in the upper secondary school in collaboration with the university. Jpn. J. Biol. Educ. 58 (3), 98-113.
  3. Zhou, Q. Q., Chen, Y. P., Wei, Q. -Q., Cao, B., Wu, Y., Zhao, B., Ou, R. W., Yang, J., Chen, X. P., Hadano, S., and Shang, H. -F. (2017) Mutation screening of the CHCHD10 gene in Chinese patients with amyotrophic lateral sclerosis. Mol. Neurobiol. 54 (5), 3189-3194.
  4. Moriya, Y., Nagata, E., Fujii, N., Satoh, T., Ogawa, H., Hadano, S., and Takizawa, S. (2017) Inositol hexakisphosphate kinase 2 is a pre-symptomatic biomarker for amyotrophic lateral sclerosis. Tokai J. Exp. Clin. Med. 42 (1), 13-18.

2016

  1. Chen, Y. P., Wei, Q. Q., Chen, X. P., Li, C. Y., Cao, B., Ou, R. W., Hadano, S., and Shang, H. -F. (2016) Aberration of miRNAs expression in leukocytes from sporadic amyotrophic lateral sclerosis. Front. Mol. Neurosci. 9, Article 69, 17 August 2016, doi: 10.3389/fnmol.2016.00069.
  2. Hadano, S., Mitsui, S., Pan, L., Otomo, A., Kubo, M., Sato, K., Ono, S., Onodera, W., Abe, K., Chen, X. P., Koike, M., Uchiyama, Y., Aoki, M., Warabi, E., Yamamoto, M., Ishii, T., Yanagawa, T., Shang, H. -F., and Yoshii, F. (2016) Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice. Hum. Mol. Genet. 25 (15), 3321-3340.
  3. Klionsky, D. J. et al , (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12 (1), 1-222.
  4. Fujitani, K., Otomo, A., Wada, M., Takamatsu, N., and Ito, M. (2016) Sexually dimorphic expression of Dmrt1 and γH2AX in germ stem cells during gonadal development in Xenopus laevis. FEBS Open Bio 6 (4), 276-284.

2015

  1. Yang, Y., Tang, L., Zhang, N., Pan, L., Hadano, S., and Fan, D. -S. (2015) Six SQSTM1 mutations in a Chinese amyotrophic lateral sclerosis cohort. Amyotroph. Lateral Scler. Frontotempo. Degen. 16　(5-6), 378-384.

2014

  1. Chen, Y. P., Zheng, Z. Z., Chen, X. P., Huang, R., Yang, Y., Yuan, L. X., Pan, L., Hadano, S., and Shang, H. -F. (2014) SQSTM1 mutations in Han Chinese populations with sporadic amyotrophic lateral sclerosis. Neurobiol. Aging 35 (3), 726.e7-726.e9.
  2. Hadano, S. (2014) Principles for biomedical research involving laboratory animals and their regulations. (JP) Journal of Japanese Cosmetic Science Society 38 (4), 250-257.
  3. Suyama, K., Watanabe, M., Sakabe, K., Otomo, A., Okada, Y., Terayama, H., Imai, T., and Mochida, J. (2014) GRP78 suppresses lipid peroxidation and promotes cellular antioxidant levels in glial cells following hydrogen peroxide exposure. PLoS ONE. 9 (1), e86951.

2013

2012

  1. Kanno, T., Tanaka, K., Yanagisawa, Y., Yasutake, K., Hadano, S., Yoshii, F., Hirayama, N., and Ikeda, J. -E. (2012) A novel small-molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy)acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: Therapeutic implications for ALS. Free Radical Biol. Med. 53 (11), 2028-2042.
  2. Pan, L., Yoshii, Y., Otomo, A., Ogawa, H., Iwasaki, Y., Shang, H. -F., and Hadano, S. (2012) Different human copper-zinc superoxide dismutase mutants, SOD1G93A and SOD1H46R, exert distinct harmful effects on gross phenotype in mice. PLoS ONE 7 (3), e33409.
  3. Otomo, A., Pan, L., and Hadano, S. (2012) Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases. Neurol. Res. Int. 2012, Article ID 498428, doi:10.1155/2012/498428.

2011

  1. Tanaka, K., Kanno, T., Yanagisawa, Y., Yasutake, K., Hadano, S., Yoshii, F., and Ikeda, J. -E. (2011) Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis. Exp. Neurol. 232 (1), 41-52.
  2. Yoshii, Y., Otomo, A., Pan, L., Ohtsuka, M., and Hadano, S. (2011) Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1H46R transgenic mouse model of ALS. Neurosci. Res. 70 (3), 321-329.
  3. Otomo, A., Kunita, R., Suzuki-Utsunomiya, K., Ikeda, J. -E., and Hadano, S. (2011) Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation. FEBS Lett. 585 (5), 730-736.

2010

  1. Hadano, S., Yoshii, Y., Otomo, A., Kunita, R., Suzuki-Utsunomiya, K., Pan, L., Kakuta, S., Iwasaki, Y., Iwakura, Y., and Ikeda, J. -E. (2010) Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice. Neurosci. Res. 68 (2), 131-136.
  2. Hadano, S., Otomo, A., Kunita, R., Suzuki-Utsunomiya, K., Akatsuka, A., Koike, M., Aoki, M., Uchiyama, Y., Itoyama, Y., and Ikeda, J. -E. (2010) Loss of ALS2/alsin exacerbates motor dysfunction in a SOD1H46R-expressing mouse ALS model by disturbing endolysosomal trafficking. PLoS ONE 5 (3), e9805.
  3. Yoshii, Y., Hadano, S., Otomo, A., Kawabe, K., Ikeda, K., and Iwasaki, Y. (2010) Lower serum lipid levels are related to respiratory impairment in patients with ALS. Neurology 74 (24), 2027; author reply 2027-2028.

2009

  1. Yoshii, Y., Hadano, S., Otomo, A., Suzuki, K., Ikeda, K., Ikeda, J. -E., and Iwasaki, Y. (2009) Natural history of young-adult amyotrophic lateral sclerosis. Neurology 73 (8), 648-649; author reply 649-650.

2008

  1. Tanaka, K., Okada, Y., Kanno, T., Otomo, A., Yanagisawa, Y., Shouguchi-Miyata, J., Suga, E., Kohiki, E., Onoe, K., Osuga, H., Aoki, M., Hadano, S., Itoyama, Y., and Ikeda, J. -E. (2008) A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice. Exp. Neurol. 211 (2), 378-386.
  2. Otomo, A., Kunita, R., Suzuki-Utsunomiya, K., Mizumura, H., Onoe, K., Osuga, H., Hadano, S., and Ikeda, J. -E. (2008) ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth. Biochem. Biophys. Res. Commn. 370 (1), 87-92.

2007

  1. Kunita, R., Otomo, A., Mizumura, H., Suzuki-Utsunomiya, K., Hadano, S., and Ikeda, J. -E. (2007) The Rab5 activator ALS2/alsin acts as a novel Rac1 effector through Rac1-activated endocytosis. J. Biol. Chem. 282 (22), 16599-16611.
  2. Suzuki-Utsunomiya, K., Hadano, S., Otomo, A., Kunita, R., Mizumura, H., Osuga, H., and Ikeda, J. -E. (2007) ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics. Biochem. Biophys. Res. Commn. 354 (2), 491-497.
  3. Hadano, S., Kunita, R., Otomo, A., Suzuki-Utsunomiya, K., and Ikeda, J. -E. (2007) Molecular and cellular function of ALS2/alsin: Implication of membrane dynamics in neuronal development and degeneration. Neurochem. Int. 51 (2-4), 74-84.

2006

  1. Hadano, S., Benn, S. C., Kakuta, S., Otomo, A., Sudo, K., Kunita, R., Suzuki-Utsunomiya, K., Mizumura, H., Shefner, J. M., Cox, G. A., Iwakura, Y., Brown, R. H., Jr., and Ikeda, J. -E. (2006) Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking. Hum. Mol. Genet. 15 (2), 233-250.

2005

  1. Okada, Y., Sakai, H., Kohiki, E., Suga, E., Yanagisawa, Y., Tanaka, K., Hadano, S., Osuga, H., and Ikeda, J. -E. (2005) A Dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein. J. Cereb. Blood Flow Metab. 25 (7), 794-806.
  2. Hadano, S. and Ikeda, J. -E. (2005) Purification and functional analyses of ALS2 and its homologue. Methods Enzymol. vol. 403, GTPases Regulating Membrane Targeting and Fusion (Edited by William E. Balch, Channing J. Der, and Alan Hall), Elsevier Inc., San Diego/California, U.S.A., pp310-321.

2004

  1. Hadano, S., Otomo, A., Suzuki-Utsunomiya, K., Kunita, R., Yanagisawa, Y., Showguchi-Miyata, J., Mizumura, H., and Ikeda, J. -E. (2004) ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics. FEBS Lett. 575 (1-3), 64-70.
  2. Kunita, R., Otomo, A., Mizumura, H., Suzuki, K., Showguchi-Miyata, J., Yanagisawa, Y., Hadano, S., and Ikeda, J. -E. (2004) Homo-oligomerization of ALS2 through its unique carboxy-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking. J. Biol. Chem. 279 (37), 38626-38635.

2003

  1. Nagano, I., Murakami, T., Shiote, M., Manabe, Y., Hadano, S., Yanagisawa, Y., Ikeda, J. -E., and Abe, K. (2003) Single-nucleotide polymorphisms in uncoding regions of ALS2 gene of Japanese patients with autosomal-recessive amyotrophic lateral sclerosis. Neurol. Res. 25 (5), 505-509.
  2. Otomo, A., Hadano, S., Okada, T., Mizumura, H., Kunita, R., Nishijima, H., Showguchi-Miyata, J., Yanagisawa, Y., Kohiki, E., Suga, E., Yasuda, M., Osuga, H., Nishimoto, T., Narumiya, S., and Ikeda, J. -E. (2003) ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics. Hum. Mol. Genet. 12 (14), 1671-1687.
  3. Hadano, S. (2003) ALS2, the novel gene for a form of recessive amyotrophic lateral sclerosis. -implication in the pathogenesis for motor neuron diseases. (JP) Igaku no Ayumi 205 (2), 119-123.

2002

  1. Singaraja, R. R., Hadano, S., Metzler, M., Givan, S., Wellington, C. L., Warby, S., Yanai, A., Gutekunst, C. -A., Leavitt, B. R., Yi, H., Fichter, K., Gan, L., McCutcheon, K., Chopra, V., Michel, J., Hersch, S. M., Ikeda, J. -E., and Hayden, M. R. (2002) HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. Hum. Mol. Genet. 11 (23), 2815-2828.
  2. Okada, T., Gondo, Y., Goto, J., Kanazawa, I., Hadano, S., and Ikeda, J. -E. (2002) Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 gene encoding a functional deubiquitinating enzyme. Hum. Genet. 110 (4), 302-313.
  3. Xu, M., Okada, T., Sakai, H., Miyamoto, N., Yanagisawa, Y., MacKenzie, A. E., Hadano, S., and Ikeda, J. -E. (2002) Functional human NAIP promoter and transcriptional elements of the human NAIP and psiNAIP genes. Biochim. Biophys. Acta 1574 (1), 35-50.
  4. Kunita, R., Otomo, A., and Ikeda, J. -E. (2002) Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain. Genomics 80 (5), 456-460.
  5. Hadano, S. (2002) Causative genes for familial amyotrophic lateral sclerosis. (JP) Seikagaku 74 (6), 483-489.
  6. Hadano, S. (2002) Genetic and genomic approaches for identification of genes underlying amyotrophic lateral sclerosis. (JP) Genome Med. (Genomu Igaku) 2 (3), 231-240.

2001

  1. Hadano, S., Hand, C. K., Osuga, H., Yanagisawa, Y., Otomo, A., Devon, R. S., Miyamoto, N., Showguchi-Miyata, J., Okada, Y., Singaraja, R., Figlewicz, D. A., Kwiatkowski, T., Hosler, B. A., Sagie, T., Skaug, J., Nasir, J., Brown, R. H., Jr., Scherer, S. W., Rouleau, G. A., Hayden, M. R., and Ikeda, J. -E. (2001) A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. Nat. Genet. 29 (2), 166-173.
  2. Hadano, S., Yanagisawa, Y., Skaug, J., Fichter, K., Nasir, J., Martindale, D., Koop, B. F., Scherer, S. W., Nicholson, D. W., Rouleau, G. A., Ikeda, J. -E., and Hayden, M. R. (2001) Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: Candidate genes for ALS2. Genomics 71 (2), 200-213.
  3. Hadano, S. and Ikeda, J. -E. (2001) Advances in understanding the molecular pathogenesis of Huntington's disease. (JP) Neurol. Med. 54 (2), 114-121.
  4. Hadano, S. (2001) Advances in understanding of the molecular pathogenesis for amyotrophic lateral sclerosis (ALS). (JP) Exp. Med. (Jikken Igaku) 19 (17), 2283-2288.

2000

  1. Matsuyama, N., Hadano, S., Onoe, K., Osuga, H., Showguchi-Miyata, J., Gondo, Y., and Ikeda, J. -E. (2000) Identification and characterization of the miniature pig Huntington's disease gene homolog: evidence for conservation and polymorphism in the CAG triplet repeat. Genomics 69 (1), 72-85.
  2. Saitoh, Y., Miyamoto, N., Okada, T., Gondo, Y., Showguchi-Miyata, J., Hadano, S., and Ikeda, J. -E. (2000) The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promotor. Genomics 67 (3), 291-300.

1999

  1. Yamamoto, K., Sakai, H., Hadano, S., Gondo, Y., and Ikeda, J. -E. (1999) Identification of two distinct transcripts for the neuronal apoptosis inhibitory protein (NAIP) gene. Biochem. Biophys. Res. Commn. 264 (3), 998-1006.
  2. Hadano, S., Nasir, J., Nichol, K., Rasper, D. M., Vaillancourt, J. P., Sherer, S. W., Beatty, B. G., Ikeda, J. -E., Nicholson, D. W., and Hayden, M. R. (1999) Genomic organization of the human caspase-9 gene on chromosome 1p36.1-p36.3. Mammal. Genome 10 (7), 757-760.
  3. Hadano, S., Nichol, K., Brinkman, R. R., Nasir, J., Martindale, D., Koop, B. F., Nicholson, D. W., Scherer, S. W., Ikeda, J. -E., and Hayden, M. R. (1999) A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34. Genomics 55 (1), 106-112.

1998

  1. Hadano, S., Ishida, Y., and Ikeda, J. -E. (1998) The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3. DNA Res. 5 (3), 177-186.
  2. Rasper, D. M., Vaillancourt, J. P., Hadano, S., Houtzager, V. M., Seiden, I., Keen, S. L. C., Tawa, P., Xanthoudakis, S., Nasir, J., Martindale, D., Koop, B. F., Peterson, E. P., Thornberry, N. A., Huang, J., MacPherson, D. P., Black, S. C., Hornung, F., Lenardo, M. J., Hayden, M. R., Roy, S., and Nicholson, D. W. (1998) Cell death attenuation by 'usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex. Cell Death Differ. 5 (4), 271-288.

1997

  1. Kogi, M., Fukushige, S., Lefevre, C., Hadano, S., and Ikeda, J. -E. (1997) A novel tandem repeat sequence located on human chromosome 4p: Isolation and characterization. Genomics 42 (2), 278-283.
  2. Hadano, S. and Ikeda, J. -E. (1997) Dynamic mutation and neuromuscular-degenerative diseases. (JP) Saishin Igaku 52 (10), 2170-2176.
  3. Hadano, S. and Ikeda, J. -E. (1997) Transcript map and genome organization of 1-Mb of the Huntington's disease locus on human chromosome 4p16.3. (JP) Advances in Neurol. Sci. (Shinkei Kenkyu no Shinpo) 41 (3), 418-429.

1996

  1. Hadano, S., Ishida, Y., Tomiyasu, H., Yamamoto, K., Bates, G. P., and Ikeda, J. -E. (1996) Transcript map of the human chromosome 4p16.3 consisting of 627 cDNA clones derived from 1 Mb of the Huntington's disease locus. DNA Res. 3 (4), 239-255.
  2. Hadano, S. and Ikeda, J. -E. (1996) A laser-based chromosome microdissection. (JP) Soshiki Baiyou 22 (2), 55-59.

1995

  1. Hadano, S. (1995) Positional cloning. Inflammation and Immunology (Ensho to Meneki) 3 (3), 324-325.
  2. Hadano, S. and Ikeda, J. -E. (1995) Gene Therapy. (JP)J. Adult Diseases (Rinsho Seijinbyo) 25 (1), 26-31.

1994

  1. Ogasawara, M., Seino, T., Hadano, S., Kasugai, A., Ito, A., and Itakura, M. (1994) Exercise-induced prolonged hyperuricemia by continuous production and release of hypoxanthine in fast-twitch muscle in rats. Purine and Pyrimidine Metabolism 18 (1), 1-9.
  2. Ishida, Y., Hadano, S., Nagayama, T., Tomiyasu, H., Wakasa, K., and Ikeda, J. -E. (1994) Isolation and characterization of 21 novel expressed DNA sequences from the distal region of the human chromosome 4p. Genomics 22 (2), 302-312.
  3. Yokoi, H., Hadano, S., Kogi, M., Kang, X., Wakasa, K., and Ikeda, J. -E. (1994) Isolation of expressed sequences encoded by the human Xq terminal portion using microclone probes generated by laser microdissection. Genomics 20 (3), 404-411.

1993

  1. Hadano, S., Ishida, Y., Bates, G. P., Nagayama, T., Kanazawa, I., Lehrach, H., and Ikeda, J. -E. (1993) Generation of high-density DNA markers from yeast artificial chromosome DNA by single unique primer- polymerase chain reaction. Genet. Anal. Techn. Appl. 10 (5), 105-108.
  2. Hadano, S. and Ikeda, J. -E. (1993) Laser chromosome microdissection and cloning of the genetic disease loci. Nippon Rinsho 51 (9), 2240-2245.

1991

  1. Hadano, S., Watanabe, M., Yokoi, H., Kogi, M., Kondo, I., Tsuchiya, H., Kanazawa, I., Wakasa, K., and Ikeda, J. -E. (1991) Laser microdissection and single unique primer PCR allow generation of regional chromosome DNA clones from a single human chromosome. Genomics 11 (2), 364-373.