ジャーナルクラブ

2024年

  • Oct 31 (Murakami); Ogawa, T., et al. (2024) Formation and long-term culture of hiPSC-derived sensory nerve organoids using microfluidic devices. Bioengineering (Basel) 11 (8), 794.

  • Oct 17 (Hadano); Hutchings, A. J., et al. (2024) Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy. Nat. Commun. 15 (1), 8622.
  • Oct 10 (Shimakura); Cozzi, M., et al. (2024) Altered molecular and cellular mechanisms in KIF5A-associated neurodegenerative or neurodevelopmental disorders. Cell Death Dis. 15 (9), 692.

  • Sept 26 (Otomo); Scheiblich, H., et al. (2024) Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes. Neuron 112 (18), 3106-3125.e8.

  • Sept 19 (Murakami); Nebuloni, F., et al. (2024) A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy. Lab Chip 24 (13), 3252-3264.

  • Sept 12 (Hadano); Tudorica, D. A., et al. (2024) A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy. J. Cell Biol. 223 (7), e202309015.

  • Sept 5 (Shimakura); Masato, A., et al. (2024) Sequestosome-1 (SQSTM1/p62) as a target in dopamine catabolite-mediated cellular dyshomeostasis. Cell Death Dis. 15 (6), 424.

  • July 11 (Otomo); Silva, P., et al. (2024) Tumor-derived hypoxic small extracellular vesicles promote endothelial cell migration and tube formation via ALS2/Rab5/beta-catenin signaling. FASEB J. 38 (11), e23716.

  • June 27　(Shimakura); Ferrari, L., et al. (2024) Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusion. Sci. Adv. 10 (24), eadm8449.

  • June 6 (Hadano); Smith, D. M., et al. (2024) Rab30 facilitates lipid homeostasis during fasting. Nat. Commun. 15 (1), 4469.

  • May 23 (Murakami); Lecoq, P. E., et al. (2024) Influence of microgravity on spontaneous calcium activity of primary hippocampal neurons grown in microfluidic chips. NPJ Microgravity 10 (1), Pages 15.

  • May 16 (Shimakura); Barrow, E. R., et al. (2024) Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome. Cell Rep. 43 (3), 113935.

  • Apr 25 (Otomo); Kodavati, M., et al. (2024) FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease. Nat. Commun. 15 (1), 2156.

  • Apr 18 (Hadano); Zhou, X., et al. (2024) Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons. Nat. Commun. 15 (1), 3113.

  • Feb 22 (Shimakura); Feng, X., et al. (2023) Local membrane source gathering by p62 body drives autophagosome formation. Nat. Commun. 14 (1), 7338.

  • Feb 15 (Otomo); Hickey, K. L., et al. (2023) Proteome census upon nutrient stress reveals Golgiphagy membrane receptors. Nature 623 (7985), 167-174.

  • Jan 11 (Hadano); Zhang, S., et al. (2023) C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy. Nat. Commun. 14 (1), 6360.

    • 2023年

  • Nov 9 (Wang); Miny, Y., et al. (2022) Modeling neurodegenerative diseases using in vitro compartmentalized microfluidic devices. Front. Bioeng. Biotechnol. 10, 919646.

  • Oct 25 (Shimakura); Leboeuf, M., et al. (2023) ENGRAILED-1 transcription factor has a paracrine neurotrophic activity on adult spinal alpha-motoneurons. EMBO Rep. 24 (8), e56525.

  • Oct 18 (Otomo); Shelke, G. V., et al. (2023) Inhibition of endolysosome fusion increases exosome secretion. J. Cell Biol. 222 (6), e202209084.

  • Sept 28 (Hadano); Kallergi, E., et al. (2023) Profiling of purified autophagic vesicle degradome in the maturing and aging brain. Neuron 111 (15), 2329-2347 e7.

  • Sept 21 (Wang); Sorrentino, S., et al. (2022) Neurovascular signals in amyotrophic lateral sclerosis. Curr. Opin. Biotechnol. 74, 75-83.

  • Sept 7 (Shimakura); Seidel, M., et al. (2023) Propranolol reduces the accumulation of cytotoxic aggregates in C9orf72-ALS/FTD in vitro models. Curr. Res. Neurobiol. 5, 100105.

  • July 20 (Otomo); Gallagher, E. R. & and Holzbaur, E. L. F. (2023) The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy. Cell Rep. 42 (2), 11203.7

  • July 13 (Hadano); Jimenez-Moreno, N., et al. (2023) ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience. J. Cell Biol. 222 (5), e202303008.

  • July 6 (Wang); Osaki, T., et al. (2018) Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons. Sci. Adv. 4 (10), eaat5847.

  • June 29 (Shimakura); Rovira, R., et al. (2022) The lysosomal proteome of senescent cells contributes to the senescence secretome. Aging Cell 21 (10), e13707.

  • June 22 (Otomo); Schuhmacher, J. S., et al. (2023) The Rab5 effector FERRY links early endosomes with mRNA localization.Aging Cell 21 (10), e13707.

  • June 15 (Hadano); Kurusu, R., et al. (2023) Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex. Dev. Cell 58, in press; DOI: 10.1016/j.devcel.2023.04.015.

  • June 8 (Wang); Marshall, K. L., et al. (2023) Enhanced axonal regeneration of ALS patient iPSC-derived motor neurons harboring SOD1(A4V) mutation. Sci. Rep. 13 (1), Pages 5597.

  • June 1 (Shimakura); Croft, C. L., et al. (2022) Optical pulse labeling studies reveal exogenous seeding slows alpha-synuclein clearance. NPJ Parkinsons Dis. 8 (1), Pages 173.

  • May 18 (Otomo); Neel, D. V., et al. (2023) Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration. Neuron 111 (8), 1222-1240 e9.

  • May 10 (Hadano); Baughn, M. W., et al. (2023) Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies. Science 379 (6637), 1140-1149.

  • Apr 20 (Wang); Park, J., et al. (2014) A microchip for quantitative analysis of CNS axon growth under localized biomolecular treatments. J. Neurosci. Methods 221, 166-174.

  • Apr 13 (Shimakura); Xia, Q., et al. (2023) Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy. Cell Biosci. 13 (1), Page 37.

  • Mar 30 (Otomo); Coelho, P. P., et al. (2022) Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation. Nat. Commun. 13 (1), Page 3812.

  • Mar 9 (Murakami); Stoklund Dittlau, K., et al. (2023) FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms. Mol. Neurodegener. 18 (1), Page 5.

  • Mar 2 (Hadano); Hung, S. T., et al. (2023) PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. Cell 186 (4), 786–802.e28.

  • Feb 9 (Yamaguchi); Morizawa, Y. M., et al. (2022) Synaptic pruning through glial synapse engulfment upon motor learning. Nat. Neurosci. 25 (11), 1458-1469.

  • Feb 2 (Yudahira); Stoklund Dittlau, K., et al. (2021) Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition. Stem Cell Rep. 16 (9), 2213-2227.

  • Jan 12 (Shimakura); Shimobayashi, S. F. & Ohsaki, Y. (2019) Universal phase behaviors of intracellular lipid droplets. Proc. Natl. Acad. Sci. U.S.A. 116 (51), 25440-25445.

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