ジャーナルクラブ

2018

  • November 8 (Shimakura); Kunita, R., et al. (2004) Homo-oligomerization of ALS2 through its unique carboxy-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking. J. Biol. Chem. 279, 38626-38635.
  • October 25 (Mitsui); Lee, J., et al. (2018) Secretion of misfolded cytosolic proteins from mammalian cells is independent of chaperone-mediated autophagy. J. Biol. Chem. 293, 14359-14370.
  • October 18 (Kushida); Osaki, T., et al. (2018) Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons. Sci. Adv. 4, eaat5847.
  • October 4 (Sato); Nokes, R., et al. (2008) Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells. J. Cell Biol.
  • September 27 (Ono); Puri, C., et al. (2018) The RAB11A-positive compartment is a primary platform for autophagosome assembly mediated by WIPI2 recognition of PI3P-RAB11A. Dev. Cell 45, 114-131.
  • September 20 (Ishiyama); Hadano, S. et al. (2016) Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice. Hum. Mol. Genet. 25, 3321-3340.
  • September 6 (Otomo); Mejlvang, J., et al. (2018) Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy. J. Cell Biol. in press.
  • July 26 (Hadano); Chitiprolu, M., et al. (2018) A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy. Nat. Commun., in press.
  • July 19 (Otomo); Fernández, Á., F., et al. (2018) Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice. Nature 558, 136-140.
  • July 12 (Mitsui); Matsumoto, G., et al. (2018) N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression. Sci. Rep. 8, 9585.
  • July 5 (Kunishida); Li, W., et al. (2017) Investigation of the subcellular neurotoxicity of amyloid-β using a device integrating microfluidic perfusion and chemotactic guidance. Adv. Healthcare Mater. 6, 1600895.
  • June 28 (Sato); Arellano, J. I., et al.(2012)Development and distribution of neuronal cilia in mouse neocortex. J. Comp. Neurol. 520, 848-873.
  • June 21 (Ono); Liu, Z., et al. (2018) LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network. Hum. Mol. Genet. 27, 385-395.
  • June 14 (Otomo); Ye, M., et al. (2018) Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling. eLife 7, e33012.
  • June 7 (Hadano); Matsui, T., et al. (2018) Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17. J. Cell Biol. in press.
  • May 31 (Mitsui); Rudnick, N.D., et al. (2017) Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS. Proc. Natl. Acad. Sci., U.S.A., in press.
  • May 24 (Kunishida); Kim, H. S., et al. (2016) A Microchip for high-throughput axon growth drug screening. Micoromachines 7, 114.
  • May 17 (Sato); Taschner, M. et al. (2018) Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis. eLife, in press
  • April 26 (Ono); Steger, M., et al. (2016) Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases. elife 5, e12813.
  • April 19 (Otomo); Oguchi, M. E., et al. (2018) Rab20, a novel Rab small GTPase that negatively regulates neurite outgrowth of PC12 cells. Neurosci. Lett. 662, 324-330.
  • April 12 (Hadano); Sha, Z. et al. (2018) Rapid induction of p62 and GAB ARA PL1 upon proteasome inhibition promotes survival before autophagy activation. J. Cell Biol., in press
  • March 29 (Mitsui); Sun, D., et al. (2017) Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation. Cell Res., in press.
  • March 22 (Kushida); Bhattacharjee, N. and Folch, A. (2017) Large-scale microfluidic gradient arrays reveal axon guidance behaviors in hippocampal neurons. Microsys. Nanoengine. 3, 17003.
  • March 8 (Sato); Yamamoto, K., et al. (2014) Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein kinase C gamma that causes spinocerebellar ataxia type14. Front. Physiol. 5, Article 126.
  • March 1 (Ono); Vetter, M., et al. (2018) Crystal structure of tetrameric human Rabin8 GEF domain. Proteins 2018, 1-9.
  • February 22 (Otomo); Mikhaylova, M., et al. (2016) A dendritic Golgi satellite between ERGIC and retromer. Cell Rep. 14, 189-199.
  • February 15 (Hadano); Naumann, M., et al. (2018) Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation. Nat. Commun., in press.
  • February 8 (Shirakawa); Carroll, B., et al. (2018) Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis. Nat. Commun. 9, 256.
  • February 1 (Mitsui); Liu, G., et al. (2017) Endocytosis regulates TDP-43 toxicity and turnover. Nat. Commn.
  • January 18 (Kushida); Yoshida, S., et al. (2016) Mobile microplates for morphological control and assembly of individual neural cells. Adv. Healthcare Mater. 5, 415-420.