研究業績

2021年

原著論文

1. Motosugi N, Okada C, Sugiyama A, Kimura M, Shiina T, Umezawa A, Akutsu H, Fukuda A. Genetic ablation of lncRNA XACT does not change expression dosage of X-linked genes but impacts differentiation potential in female human pluripotent stem cells. Cell reports. Accepted.
2. Kulski JK, Suzuki S, Shiina T. Haplotype switching and dimorphic transposable elements in the human extended MHC class II region. Front Genet. Accepted.
3. Imaeda N, Ando A, Matsubara T, Takasu M, Nishii N, Miyamoto A, Oshima S, Kametani Y, Suzuki S, Shiina T, Ono T, Kulski JK, Kitagawa H. Stillbirth rates, and its association with swine leucocyte antigen class II haplotypes in Microminipigs. Animal Bioscience. Accepted.
4. Ishigaki H, Pham VL, Ishida H, Okahara J, Kaneko S, Shiina T, Nakayama M, Itoh Y, Ogasawara K. No Tumorigenicity of Allogeneic Induced Pluripotent Stem Cells in Major Histocompatibility Complex-matched Cynomolgus Macaques. Cell Transplant. 2021 Jan-Dec;30:963689721992066. doi: 10.1177/0963689721992066.
5. Kando C, Ota N, Ono K, Tsunokawa M, Niino M, Tsuda T, Shiina T, Kita YF, Suzuki S. Subspecies classification of domestic bred Gentoo penguins by diversity analysis of mitochondrial DNA. Ornithol. Sci. 20: 93-100, 2021.
6. Kulski JK, Suzuki S, Shiina T. SNP-Density Crossover Maps of Polymorphic Transposable Elements and HLA Genes Within MHC Class I Haplotype Blocks and Junction. Front Genet. 2021 Jan 18;11:594318. doi: 10.3389/fgene.2020.594318.

2020年

原著論文

1. Ohshima S, Matsubara T, Miyamoto A, Shigenari A, Imaeda N, Takasu M, Tanaka M, Shiina T, Suzuki S, Hirayama N, Kitagawa H, Kulski JK, Ando A, Kametani Y. 156. Preparation and characterization of monoclonal antibodies recognizing two CD4 isotypes of Microminipigs. PLoS One. 2020 Nov 25;15(11):e0242572. doi: 10.1371/journal.pone.0242572.
2. Kisu I, Kato Y, Masugi Y, Ishigaki H, Yamada Y, Matsubara K, Obara H, Emoto K, Matoba Y, Adachi M, Banno K, Saiki Y, Sasamura T, Itagaki I, Kawamoto I, Iwatani C, Nakagawa T, Murase W, Tsuchiya H, Urano H, Ema M, Ogasawara K, Aoki D, Nakagawa K, Shiina T. First successful delivery after uterus transplantation in MHC-defined cynomolgus macaques. J Clin Med. 2020 Nov 17;9(11):3694. doi: 10.3390/jcm9113694.
3. Saxena A, Suzuki S, Mourya M, Shiina T, Kanga U. Novel and extended HLA class I and II alleles encountered in Kashmiri Brahmin population from North India. HLA. 2020 Oct;96(4):487-489. doi: 10.1111/tan.13997.
4. Oyama M, Ohnuki Y, Inoue M, Uruha A, Yamashita S, Yutani S, Tanboon J, Nakahara J, Suzuki S, Shiina T, Nishino I, Suzuki S. HLA-DRB1 allele and autoantibody profiles in Japanese patients with inclusion body myositis. PLoS One. 2020 Aug 18;15(8):e0237890. doi: 10.1371/journal.pone.0237890.
5. Kisu I, Emoto K, Masugi Y, Yamada Y, Matsubara K, Obara H, Matoba Y, Banno K, Kato Y, Saiki Y, Itagaki I, Kawamoto I, Iwatani C, Murase M, Nakagawa T, Tsuchiya H, Ishigaki H, Urano H, Ema M, Ogasawara K, Aoki D, Nakagawa K, Shiina T. Clinical features of irreversible rejection after allogeneic uterus transplantation in cynomolgus macaques. Sci Rep. 2020 Aug 17;10(1):13910. doi: 10.1038/s41598-020-70914-1.
6. Okano M, Miyamae J, Suzuki S, Nishiya K, Katakura F, Kulski JK, Moritomo T, Shiina T. Identification of Novel Alleles and Structural Haplotypes of Major Histocompatibility Complex Class I and DRB Genes in Domestic Cat (Felis catus) by a Newly Developed NGS-Based Genotyping Method. Front Genet. 2020 Jul 15;11:750. doi: 10.3389/fgene.2020.00750.
7. Yamamoto F, Suzuki S, Mizutani A, Shigenari A, Ito S, Kametani Y, Kato S, Fernandez-Viña M, Murata M, Morishima S, Morishima Y, Tanaka M, Kulski JK, Bahram S, Shiina T. Capturing Differential Allele-Level Expression and Genotypes of All Classical HLA Loci and Haplotypes by a New Capture RNA-Seq Method. Front Immunol. 2020 May 29;11:941. doi: 10.3389/fimmu.2020.00941.
8. Kikkawa E, Shiina T, Shigenari A, Ozaki Y, Suzuki S, Ando K, Onizuka M. Detection of 6pLOH in an aplastic anemia patient by in phase HLA genotyping. HLA. 2020 May;95(5):465-469. doi: 10.1111/tan.13807.
9. Kashiwagi H, Ishimoto H, Izumi SI, Seki T, Kinami R, Otomo A, Takahashi K, Kametani F, Hirayama N, Sasaki E, Shiina T, Sakabe K, Mikami M, Kametani Y. Human PZP and common marmoset A2ML1 as pregnancy related proteins. Sci Rep. 2020 Mar 20;10(1):5088. doi: 10.1038/s41598-020-61714-8.

総説

1. 椎名 隆、鈴木 進悟、大貫 優子、岡 晃. HLA関連疾患研究の最新情報. 臨床免疫・アレルギー科. 74(5): 449-455, 2020
2. 椎名 隆. NGSの活用によるHLA DNAタイピング検査法の特徴. SRL宝冠 41: 4-12, 2020.
3. Kisu I, Banno K, Obara H, Kato Y, Yamada Y, Matsubara K, Matoba Y, Adachi M, Emoto K, Masugi Y, Saiki Y, Ishigaki H, Itagaki I, Kawamoto I, Iwatani C, Nakagawa T, Murase M, Tsuchiya H, Nakagawa K, Shiina T, Aoki D. Experimental techniques for the development of a uterus transplantation model in cynomolgus macaques. J Obstet Gynaecol Res. 2020 Nov;46(11):2251-2260. doi: 10.1111/jog.14477.
4. de Groot NG, Otting N, Maccari G, Robinson J, Hammond JA, Blancher A, Lafont BAP, Guethlein LA, Wroblewski EE, Marsh SGE, Shiina T, Walter L, Vigilant L, Parham P, O'Connor DH, Bontrop RE. Correction to: Nomenclature report 2019: major histocompatibility complex genes and alleles of great and small ape and old and new world monkey species. Immunogenetics. 2020 Feb;72(1-2):131-132. doi: 10.1007/s00251-019-01146-5.

2019年

原著論文

1. Tanaka M, Makiuchi T, Komiyama T, Shiina T, Osaki K, Tachibana H. Whole genome sequencing of Entamoeba nuttalli reveals mammalian host-related molecular signatures and a novel octapeptide-repeat surface protein. PLoS Negl Trop Dis. 2019 Dec 5;13(12):e0007923. doi: 10.1371/journal.pntd.0007923.
2. Miyamae J, Yagi H, Sato K, Okano M, Nishiya K, Katakura F, Sakai M, Nakayama T, Moritomo T, Shiina T. Evaluation of alloreactive T cells based on the degree of MHC incompatibility using flow cytometric mixed lymphocyte reaction assay in dogs. Immunogenetics. 2019 Nov;71(10):635-645. doi: 10.1007/s00251-019-01147-4.
3. Kisu I, Ishigaki H, Emoto K, Kato Y, Yamada Y, Matsubara K, Obara H, Masugi Y, Matoba Y, Adachi M, Banno K, Saiki Y, Itagaki I, Kawamoto I, Iwatani C, Nakagawa T, Tsuchiya H, Sasamura T, Urano H, Ema M, Ogasawara K, Aoki D, Nakagawa K, Shiina T. Long-Term Outcome and Rejection After Allogeneic Uterus Transplantation in Cynomolgus Macaques. J Clin Med. 2019 Oct 1;8(10). pii: E1572. doi: 10.3390/jcm8101572.
4. Ando A, Imaeda N, Matsubara T, Takasu M, Miyamoto A, Oshima S, Nishii N, Kametani Y, Shiina T, Kulski JK, Kitagawa H. Genetic Association between Swine Leukocyte Antigen Class II Haplotypes and Reproduction Traits in Microminipigs. Cells. 2019 Jul 26;8(8). pii: E783. doi: 10.3390/cells8080783.
5. Tanboon J, Sanmaneechai O, Charuvanij S, Sangruchi T, Galindo-Feria AS, Lundberg IE, Ohnuki Y, Shiina T, Suzuki S, Nishino I. Concurrent positive anti-3-hydroxy-3-methylglutaryl-coenzyme a reductase antibody with reducing body myopathy: Possible double trouble. Neuromuscul Disord. 2019 Jul;29(7):543-548. doi: 10.1016/j.nmd.2019.05.007.
6. Shiina T, Suzuki S, Congy-Jolivet N, Aarnink A, Garchon HJ, Dereuddre-Bosquet N, Vaslin B, Tchitchek N, Desjardins D, Autran B, Lambotte O, Theodorou I, Le Grand R, Blancher A. Cynomolgus macaque IL37 polymorphism and control of SIV infection. Sci Rep. 2019 May 28;9(1):7981. doi: 10.1038/s41598-019-44235-x.
7. Yamamoto Y, Morita D, Shima Y, Midorikawa A, Mizutani T, Suzuki J, Mori N, Shiina T, Inoko H, Tanaka Y, Mikami B, Sugita M. Identification and Structure of an MHC Class I-Encoded Protein with the Potential to Present N-Myristoylated 4-mer Peptides to T Cells. J Immunol. 2019 Jun 15;202(12):3349-3358. doi: 10.4049/jimmunol.1900087.
8. Seki M, Uruha A, Ohnuki Y, Kamada S, Noda T, Onda A, Ohira M, Isami A, Hiramatsu S, Hibino M, Nakane S, Noda S, Yutani S, Hanazono A, Yaguchi H, Takao M, Shiina T, Katsuno M, Nakahara J, Matsubara S, Nishino I, Suzuki S. Inflammatory myopathy associated with PD-1 inhibitors. J Autoimmun. 2019 Jun;100:105-113. doi: 10.1016/j.jaut.2019.03.005.
9. Osoegawa K, Vayntrub TA, Wenda S, De Santis D, Barsakis K, Ivanova M, Hsu S, Barone J, Holdsworth R, Diviney M, Askar M, Willis A, Railton D, Laflin S, Gendzekhadze K, Oki A, Sacchi N, Mazzocco M, Andreani M, Ameen R, Stavropoulos-Giokas C, Dinou A, Torres M, Dos Santos Francisco R, Serra-Pages C, Goodridge D, Balladares S, Bettinotti MP, Iglehart B, Kashi Z, Martin R, Saw CL, Ragoussis J, Downing J, Navarrete C, Chong W, Saito K, Petrek M, Tokic S, Padros K, Beatriz Rodriguez M, Zakharova V, Shragina O, Marino SR, Brown NK, Shiina T, Suzuki S, Spierings E, Zhang Q, Yin Y, Morris GP, Hernandez A, Ruiz P, Khor SS, Tokunaga K, Geretz A, Thomas R, Yamamoto F, Mallempati KC, Gangavarapu S, Kanga U, Tyagi S, Marsh SGE, Bultitude WP, Liu X, Cao D, Penning M, Hurley CK, Cesbron A, Mueller C, Mytilineos J, Weimer ET, Bengtsson M, Fischer G, Hansen JA, Chang CJ, Mack SJ, Creary LE, Fernandez-Viña MA. Quality control project of NGS HLA genotyping for the 17th International HLA and Immunogenetics Workshop. Hum Immunol. 2019 Apr;80(4):228-236. doi: 10.1016/j.humimm.2019.01.009.

総説

1. Shiina T, Blancher A. The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine. Cells. 2019 Aug 26;8(9). pii: E978. doi: 10.3390/cells8090978.
2. Kulski JK, Shiina T, Dijkstra JM. Genomic Diversity of the Major Histocompatibility Complex in Health and Disease. Cells. 2019 Oct 17;8(10). pii: E1270. doi: 10.3390/cells8101270.
3. 岡野 雅春、森友 忠昭、椎名 隆. ネコMHC遺伝子の特徴と獣医療への応用. MHC. 2019. 26: 204-211.
4. 椎名 隆、細道 一善. NGSを利用したHLAゲノム・遺伝子解析への新たな展望. 実験医学. 2019. 37: 2259-2264.
5. 中條 聖子、椎名 隆. HLA DNAタイピングに関する情報検索. 遺伝子医学. 2019. 30: 90-102.
6. 椎名 隆、中條 聖子. NGSによるHLA遺伝子のDNAタイピング (NGS-SBT) 法の特徴と臨床応用. 日本染色体遺伝子検査学会誌. 2019. 37: 16-24.
7. 椎名 隆、安藤 麻子. HLAタイピング技術の進歩. 血液フロンティア. 2019. 29: 116-122.

2018年

原著論文

1. Imaeda N, Ando A, Takasu M, Matsubara T, Nishii N, Takashima S, Shigenari A, Shiina T, Kitagawa H. Influence of swine leukocyte antigen haplotype on serum antibody titers against swine erysipelas vaccine and reproductive and meat production traits of SLA-defined selectively bred Duroc pigs. J Vet Med Sci. 2018 Nov 9;80(11):1662-1668. doi: 10.1292/jvms.18-0027.
2. Suzuki S, Ranade S, Osaki K, Ito S, Shigenari A, Ohnuki Y, Oka A, Masuya A, Harting J, Baybayan P, Kitazume M, Sunaga J, Morishima S, Morishima Y, Inoko H, Kulski JK, Shiina T. Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform. Front Immunol. 2018 Oct 4;9:2294. doi: 10.3389/fimmu.2018.02294.
3. Takahashi K, Hayano T, Sugimoto R, Kashiwagi H, Shinoda M, Nishijima Y, Suzuki T, Suzuki S, Ohnuki Y, Kondo A, Shiina T, Nakaoka H, Inoue I, Izumi SI. Exome and copy number variation analyses of Mayer-Rokitansky-Küster- Hauser syndrome. Hum Genome Var. 2018 Sep 27;5:27. doi: 10.1038/s41439-018-0028-4.
4. de Manuel M, Shiina T, Suzuki S, Dereuddre-Bosquet N, Garchon HJ, Tanaka M, Congy-Jolivet N, Aarnink A, Le Grand R, Marques-Bonet T, Blancher A. Whole genome sequencing in the search for genes associated with the control of SIV infection in the Mauritian macaque model. Sci Rep. 2018 May 8;8(1):7131. doi: 10.1038/s41598-018-25071-x.
5. Miyamae J, Suzuki S, Katakura F, Uno S, Tanaka M, Okano M, Matsumoto T, Kulski JK, Moritomo T, Shiina T. Identification of novel polymorphisms and two distinct haplotype structures in dog leukocyte antigen class I genes: DLA-88, DLA-12 and DLA-64. Immunogenetics. 2018 Apr;70(4):237-255. doi: 10.1007/s00251-017-1031-5.
6. Matsubara T, Takasu M, Imaeda N, Nishii N, Takashima S, Nishimura T, Nishimura T, Shiina T, Ando A, Kitagawa H. Genetic association of swine leukocyte antigen class II haplotypes and body weight in Microminipigs. Asian-Australas J Anim Sci. 2018 Feb;31(2):163-166. doi: 10.5713/ajas.17.0337.
7. Morishima S, Shiina T, Suzuki S, Ogawa S, Sato-Otsubo A, Kashiwase K, Azuma F, Yabe T, Satake M, Kato S, Kodera Y, Sasazuki T, Morishima Y; Japan Marrow Donor Program. Evolutionary basis of HLA-DPB1 alleles affects acute GVHD in unrelated donor stem cell transplantation. Blood. 2018 Feb 15;131(7):808-817. doi: 10.1182/blood-2017-08-801449.

総説

1. Ishigaki H, Shiina T, Ogasawara K. MHC-identical and transgenic cynomolgus macaques for preclinical studies. Inflamm Regen. 2018 Nov 22;38:30. doi: 10.1186/s41232-018-0088-3.
2. Kametani Y, Shiina T, Suzuki R, Sasaki E, Habu S. Comparative immunity of antigen recognition, differentiation, and other functional molecules: similarities and differences among common marmosets, humans, and mice. Exp Anim. 2018 Jul 30;67(3):301-312. doi: 10.1538/expanim.17-0150.
3. Shiina T, Suzuki S, Kulski JK, Inoko H. Super High Resolution for Single Molecule-Sequence-Based Typing of Classical HLA Loci Using Ion Torrent PGM. Methods Mol Biol. 2018;1802:115-133. doi: 10.1007/978-1-4939-8546-3_8.
4. 椎名 隆、安藤 麻子. HLAタイピング技術の進歩. 血液フロンティア. 2019. 29: 116-122.

2017年

原著論文

1. Sugita S, Makabe K, Fujii S, Iwasaki Y, Kamao H, Shiina T, Ogasawara K, Takahashi M. Detection of Retinal Pigment Epithelium-Specific Antibody in iPSC-Derived Retinal Pigment Epithelium Transplantation Models. Stem Cell Reports. 2017 Nov 14;9(5):1501-1515. doi: 10.1016/j.stemcr.2017.10.003.
2. Ishigaki H, Maeda T, Inoue H, Akagi T, Sasamura T, Ishida H, Inubushi T, Okahara J, Shiina T, Nakayama M, Itoh Y, Ogasawara K. Transplantation of iPS-Derived Tumor Cells with a Homozygous MHC Haplotype Induces GRP94 Antibody Production in MHC-Matched Macaques. Cancer Res. 2017 Nov 1;77(21):6001-6010. doi: 10.1158/0008-5472.CAN-17-0775.
3. Morizane A, Kikuchi T, Hayashi T, Mizuma H, Takara S, Doi H, Mawatari A, Glasser MF, Shiina T, Ishigaki H, Itoh Y, Okita K, Yamasaki E, Doi D, Onoe H, Ogasawara K, Yamanaka S, Takahashi J. MHC matching improves engraftment of iPSC-derived neurons in non-human primates. Nat Commun. 2017 Aug 30;8(1):385. doi: 10.1038/s41467-017-00926-5.
4. Noguchi E, Uruha A, Suzuki S, Hamanaka K, Ohnuki Y, Tsugawa J, Watanabe Y, Nakahara J, Shiina T, Suzuki N, Nishino I. Skeletal Muscle Involvement in Antisynthetase Syndrome. JAMA Neurol. 2017 Aug 1;74(8):992-999. doi: 10.1001/jamaneurol.2017.0934.
5. Watanabe N, Suzuki Y, Yonezu T, Nakagawa Y, Shiina T, Hirayama N, Inokuchi S, Inoue S. A cell-based high-throughput screening assay system for inhibitor compounds of antigen presentation by HLA class II molecule. Sci Rep. 2017 Jul 28;7(1):6798. doi: 10.1038/s41598-017-07080-4.
6. Suzuki S, Kaidow A, Meya T, Masuya A, Shiina T. Phenotypic difference between Δ(srl-recA)306 and ΔrecA::Km elucidated by next-generation sequencing combined with a long-PCR system. J Gen Appl Microbiol. 2017 Mar 17;63(1):22-27. doi: 10.2323/jgam.2016.07.002.
7. 朝治 桜子、原 ひろみ、平野 貴、半澤 惠、石毛 太一郎、細道 一善、鈴木 進悟、椎名 隆. RNA-seqによるニホンウズラの主要組織適合性複合体遺伝子座の多様性解析. DNA Polymorphism. 2017. 25: 47-51.
8. 北 夕紀、村山 美穂、小木 万布、森阪 匡通、酒井 麻衣、椎名 隆. 御蔵島に生息するミナミハンドウイルカ(Tursiops aduncus)の血縁解析. DNA Polymorphism. 2017. 25: 52-57.

総説

1. Ohnuki Y, Shiina T. HLA-DRB1 alleles in immune-mediated necrotizing myopathy. Clinical and Experimental Neuroimmunology 2017 Oct 18;8(4):313-317.
2. Shiina T, Blancher A, Inoko H, Kulski JK. Comparative genomics of the human, macaque and mouse major histocompatibility complex. Immunology. 2017 Feb;150(2):127-138. doi: 10.1111/imm.12624. Epub 2016 Jul 10.
3. 鈴木進悟、猪子英俊、椎名 隆. 日本人におけるHLA遺伝子全領域の高頻度•高精度アレル塩基配列の収集. Medical Science Digest. 2017. 43: 60-62.
4. 大貫 優子、鈴木 重明、重成 敦子、鈴木 進悟、渡邊 由里香、中原 仁、鈴木 則宏、西野 一三、椎名 隆. 免疫介在性壊死性ミオパチー（IMNM）とHLA多型. 2017. MHC 24: 46-53.
5. 鈴木 重明、大貫 優子、椎名 隆：免疫性筋疾患とHLA、Annual Review 神経 2017、鈴木則宏ら編、中外医学社、2017; p.237-242.
6. 中條 聖子、椎名 隆：NGS-SBT法によるHLA遺伝子のDNAタイピング検査、疾患・病態検査・診断法の開発、技術情報協会、2017; p120-125.

2016年

原著論文

1. Ohnuki Y, Suzuki S, Shiina T, Uruha A, Watanabe Y, Suzuki S, Izumi S, Nakahara J, Hamanaka K, Takayama K, Suzuki N, Nishino I. HLA-DRB1 alleles in immune-mediated necrotizing myopathy. Neurology. 2016 Nov 1;87(18):1954-1955.
2. Obara H, Kisu I, Kato Y, Yamada Y, Matsubara K, Emoto K, Adachi M, Matoba Y, Umene K, Nogami Y, Banno K, Tsuchiya H, Itagaki I, Kawamoto I, Nakagawa T, Ishigaki H, Itoh Y, Ogasawara K, Saiki Y, Sato SI, Nakagawa K, Shiina T, Aoki D, Kitagawa Y. Surgical technique for allogeneic uterus transplantation in macaques. Sci Rep. 2016 Oct 27;6:35989. doi: 10.1038/srep35989.
3. Shiba Y, Gomibuchi T, Seto T, Wada Y, Ichimura H, Tanaka Y, Ogasawara T, Okada K, Shiba N, Sakamoto K, Ido D, Shiina T, Ohkura M, Nakai J, Uno N, Kazuki Y, Oshimura M, Minami I, Ikeda U. Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts. Nature. 2016 Oct 20;538(7625):388-391. doi: 10.1038/nature19815.
4. Kametani Y, Ohshima S, Miyamoto A, Shigenari A, Takasu M, Imaeda N, Matsubara T, Tanaka M, Shiina T, Kamiguchi H, Suzuki R, Kitagawa H, Kulski JK, Hirayama N, Inoko H, Ando A. Production of a Locus- and Allele-Specific Monoclonal Antibody for the Characterization of SLA-1*0401 mRNA and Protein Expression Levels in MHC-Defined Microminipigs. PLoS One. 2016 Oct 19;11(10):e0164995. doi: 10.1371/journal.pone.0164995.
5. Sugita S, Iwasaki Y, Makabe K, Kamao H, Mandai M, Shiina T, Ogasawara K, Hirami Y, Kurimoto Y, Takahashi M. Successful Transplantation of Retinal Pigment Epithelial Cells from MHC Homozygote iPSCs in MHC-Matched Models. Stem Cell Reports. 2016 Oct 11;7(4):635-648. doi: 10.1016/j.stemcr.2016.08.010.
6. Ando A, Shigenari A, Kojima-Shibata C, Nakajoh M, Suzuki K, Kitagawa H, Shiina T, Inoko H, Uenishi H. Association of swine leukocyte antigen class II haplotypes and immune-related traits in a swine line selected for resistance to mycoplasmal pneumonia. Comp Immunol Microbiol Infect Dis. 2016 Oct;48:33-40. doi: 10.1016/j.cimid.2016.07.004.
7. Maruyama H, Katagiri T, Kashiwase K, Shiina T, Sato-Otsubo A, Zaimoku Y, Maruyama K, Hosokawa K, Ishiyama K, Yamazaki H, Inoko H, Ogawa S, Nakao S. Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia. Exp Hematol. 2016 Oct;44(10):931-939.e3. doi: 10.1016/j.exphem.2016.05.013.
8. Takahashi K, Nakamura E, Suzuki S, Shinoda M, Nishijima Y, Ohnuki Y, Kondo A, Shiina T, Suzuki T, Izumi S. Laparoscopic Davydov Procedure for the Creation of a Neovagina in Patients with Mayer-Rokitansky-Kuster-Hauser Syndrome: Analysis of 7 Cases. Tokai J Exp Clin Med. 2016 Jun 20;41(2):81-7.
9. Okumura N, Sakamoto Y, Fujii K, Kitano J, Nakano S, Tsujimoto Y, Nakamura S, Ueno M, Hagiya M, Hamuro J, Matsuyama A, Suzuki S, Shiina T, Kinoshita S, Koizumi N. Rho kinase inhibitor enables cell-based therapy for corneal endothelial dysfunction. Sci Rep. 2016 May 18;6:26113. doi: 10.1038/srep26113.
10. Matsuu A, Kobayashi T, Patchimasiri T, Shiina T, Suzuki S, Chaichoune K, Ratanakorn P, Hiromoto Y, Abe H, Parchariyanon S, Saito T. Pathogenicity of Genetically Similar, H5N1 Highly Pathogenic Avian Influenza Virus Strains in Chicken and the Differences in Sensitivity among Different Chicken Breeds. PLoS One. 2016 Apr 14;11(4):e0153649. doi: 10.1371/journal.pone.0153649.
11. Sakai M, Kita YF, Kogi K, Shinohara M, Morisaka T, Shiina T, Inoue-Murayama M. A wild Indo-Pacific bottlenose dolphin adopts a socially and genetically distant neonate. Sci Rep. 2016 Apr 6;6:23902. doi: 10.1038/srep23902.
12. Morishima S, Kashiwase K, Matsuo K, Azuma F, Yabe T, Sato-Otsubo A, Ogawa S, Shiina T, Satake M, Saji H, Kato S, Kodera Y, Sasazuki T, Morishima Y; Japan Marrow Donor Program. High-risk HLA alleles for severe acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation. Haematologica. 2016 Apr;101(4):491-8. doi: 10.3324/haematol.2015.136903.
13. Kawamura T, Miyagawa S, Fukushima S, Maeda A, Kashiyama N, Kawamura A, Miki K, Okita K, Yoshida Y, Shiina T, Ogasawara K, Miyagawa S, Toda K, Okuyama H, Sawa Y. Cardiomyocytes Derived from MHC-Homozygous Induced Pluripotent Stem Cells Exhibit Reduced Allogeneic Immunogenicity in MHC-Matched Non-human Primates. Stem Cell Reports. 2016 Mar 8;6(3):312-20. doi: 10.1016/j.stemcr.2016.01.012.
14. Suzuki S, Sato T, Akatsuka H, Kimura M, Shiina T. Identification of a novel HLA-C allele, HLA-C*03:313, in a Japanese individual. HLA. 2016 Mar;87(3):186-7. doi: 10.1111/tan.12750.
15. Morita D, Yamamoto Y, Mizutani T, Ishikawa T, Suzuki J, Igarashi T, Mori N, Shiina T, Inoko H, Fujita H, Iwai K, Tanaka Y, Mikami B, Sugita M. Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex. Nat Commun. 2016 Jan 13;7:10356. doi: 10.1038/ncomms10356.
16. Okudaira Y, Hosomichi K, Ozaki Y, Shiina T, Mitsunaga S. Correction of the HLA-DQB1*04:01:01 sequence at position 79 in exon 1. HLA. 2016 Jan;87(1):57-8. doi: 10.1111/tan.12712.
17. 宮前 二郎、宇野 沙恵、田中 瑞樹、片倉 文彦、森友 忠昭、難波 信一、坂井 学、亘 敏広、鈴木 進悟、椎名 隆. イヌMHCクラスⅠおよびクラスⅡ遺伝子座の多型解析とハプロタイプ推定. DNA Polymorphism. 2016. 24: 81-86.
18. 朝治 桜子、原 ひろみ、平野 貴、半澤 惠、鈴木 進悟、椎名 隆. 次世代シークエンサーによるニホンウズラの機能的主要組織適合性複合体クラスⅡB（CjIIB）遺伝子座の多様性解析. DNA Polymorphism. 2016. 24: 76-80.

総説

1. Shiina T, Suzuki S, Kulski JK. Next generation sequencing (ed. Kulski JK) MHC Genotyping in Human and Nonhuman Species by PCR-based Next-Generation Sequencing. Intech, Croatia, 2016; Chapter 3.
2. 椎名 隆、鈴木 進悟、猪子 英俊. HLA遺伝子領域のゲノム解析と腎移植. 特集/腎移植update -腎臓病学・免疫学・再生医学からの新知見. 腎臓内科・泌尿器科. 2016. 3: 138-147.

2015年

原著論文

1. Shimada S, Nunomura S, Mori S, Suemizu H, Itoh T, Takabayashi S, Okada Y, Yahata T, Shiina T, Katoh H, Suzuki R, Tani K, Ando K, Yagita H, Habu S, Sasaki E, Kametani Y. Common marmoset CD117+ hematopoietic cells possess multipotency. Int Immunol. 2015 Nov;27(11):567-77. doi: 10.1093/intimm/dxv031.
2. Shiina T, Yamada Y, Aarnink A, Suzuki S, Masuya A, Ito S, Ido D, Yamanaka H, Iwatani C, Tsuchiya H, Ishigaki H, Itoh Y, Ogasawara K, Kulski JK, Blancher A. Discovery of novel MHC-class I alleles and haplotypes in Filipino cynomolgus macaques (Macaca fascicularis) by pyrosequencing and Sanger sequencing: Mafa-class I polymorphism. Immunogenetics. 2015 Oct;67(10):563-78. doi: 10.1007/s00251-015-0867-9.
3. Mitsunaga S, Hosomichi K, Okudaira Y, Nakaoka H, Suzuki Y, Kuwana M, Sato S, Kaneko Y, Homma Y, Oka A, Shiina T, Inoko H, Inoue I. Aggregation of rare/low-frequency variants of the mitochondria respiratory chain-related proteins in rheumatoid arthritis patients. J Hum Genet. 2015 Aug;60(8):449-54. doi: 10.1038/jhg.2015.50.
4. Ozaki Y, Suzuki S, Kashiwase K, Shigenari A, Okudaira Y, Ito S, Masuya A, Azuma F, Yabe T, Morishima S, Mitsunaga S, Satake M, Ota M, Morishima Y, Kulski JK, Saito K, Inoko H, Shiina T. Cost-efficient multiplex PCR for routine genotyping of up to nine classical HLA loci in a single analytical run of multiple samples by next generation sequencing. BMC Genomics. 2015 Apr 18;16:318. doi: 10.1186/s12864-015-1514-4.
5. Yamaguchi T, Suzuki S, Okamura S, Miura Y, Tsukimori A, Nakamura I, Ito N, Masuya A, Shiina T, Matsumoto T. Evolution and single-nucleotide polymorphisms in methicillin-resistant Staphylococcus aureus strains with reduced susceptibility to vancomycin and daptomycin, based on determination of the complete genome. Antimicrob Agents Chemother. 2015;59(6):3585-7. doi: 10.1128/AAC.05159-14.
6. 朝治 桜子、鈴木 進悟、細道 一善、原 ひろみ、平野 貴、椎名 隆、半澤 惠.ニホンウズラ主要組織適合性複合体（Mhc Coja）領域のハプロタイプ解析による組換え部位の推定. DNA Polymorphism. 2015. 23: 160-163.
7. 辻本 邑、鈴木 進悟、北 夕紀、椎名 隆. 主要組織適合性複合体クラスⅡ遺伝子 (MHC-DRB1) における多型解析法の開発と遺伝学的解析. 東海大学紀要・生物医学部. 2015. 4: 9-16.

総説

1. Hosomichi K, Shiina T, Tajima A, Inoue I. The impact of next-generation sequencing technologies on HLA research. J Hum Genet. 2015 Nov;60(11):665-73. doi: 10.1038/jhg.2015.1
2. 小笠原 一誠、椎名 隆、土屋 英明. 移植免疫寛容カニクイザルコロニーの確立と再生医療への応用. 再生医療. 2015. 73: 369-373.
3. 椎名 隆、鈴木 進悟、尾崎 有紀、光永 滋樹、猪子 英俊. 次世代シークエンサーはHLAジェノタイピング法を変えるのか？. 分子リウマチ治療. 2015. 8: 17-21.
4. 椎名 隆. 次世代シークエンシングに基づくHLAゲノム・遺伝子解析. MHC. 2015. 22: 84-94.
5. 鈴木 進悟、尾崎 有紀、桝屋 安里、重成 敦子、光永 滋樹、猪子 英俊、椎名 隆. 次世代シークエンス用アリル判定プログラム(SeaBass) の開発とその検証. MHC. 2015. 22: 102-107.

2014年

原著論文

1. Ando A, Imaeda N, Ohshima S, Miyamoto A, Kaneko N, Takasu M, Shiina T, Kulski JK, Inoko H, Kitagawa H. Characterization of swine leukocyte antigen alleles and haplotypes on a novel miniature pig line, Microminipig. Anim Genet. 2014 Dec;45(6):791-8. doi: 10.1111/age.12199.
2. Kisu I, Kato Y, Tsuchiya H, Kawamoto I, Nakagawa T, Ogasawara K, Hayakawa T, Yamayoshi Y, Iketani O, Mihara M, Banno K, Sato S, Shiina T, Aoki D. Study of pharmacokinetic properties of cyclosporine A after subcutaneous injection in cynomolgus monkey. Int J Pharmacol. 2014 Aug;10(8):487-493. DOI: 10.3923/ijp.2014.487.493.
3. Kisu I, Mihara M, Banno K, Hara H, Masugi Y, Araki J, Iida T, Yamada Y, Kato Y, Shiina T, Suganuma N, Aoki D. Uterus allotransplantation in cynomolgus macaque: a preliminary experience with non-human primate models. J Obstet Gynaecol Res. 2014 Apr;40(4):907-18. doi: 10.1111/jog.12302.
4. Blancher A, Aarnink A, Yamada Y, Tanaka K, Yamanaka H, Shiina T. Study of MHC class II region polymorphism in the Filipino cynomolgus macaque population. Immunogenetics. 2014 Apr;66(4):219-30. doi: 10.1007/s00251-014-0764-7.
5. Kagawa T, Oka A, Kobayashi Y, Hiasa Y, Kitamura T, Sakugawa H, Adachi Y, Anzai K, Tsuruya K, Arase Y, Hirose S, Shiraishi K, Shiina T, Sato T, Wang T, Tanaka M, Hayashi H, Kawabe N, Robinson PN, Zemojtel T, Mine T. Recessive inheritance of population-specific intronic LINE-1 insertion causes a rotor syndrome phenotype. Hum Mutat. 2015 Mar;36(3):327-32. doi: 10.1002/humu.22745.
6. Kono A, Brameier M, Roos C, Suzuki S, Shigenari A, Kametani Y, Kitaura K, Matsutani T, Suzuki R, Inoko H, Walter L, Shiina T. Genomic sequence analysis of the MHC class I G/F segment in common marmoset (Callithrix jacchus). J Immunol. 2014 Apr 1;192(7):3239-46. doi: 10.4049/jimmunol.1302745.
7. Wada A, Shiina T, Michino J, Yasumura S, Sugiyama T. A novel HLA-B allele, HLA-B*44:184, identified by super high-resolution single-molecule sequence-based typing in a Japanese individual. Tissue Antigens. 2014 Mar;83(3):198-9. doi: 10.1111/tan.12284.
8. Ozaki Y, Suzuki S, Shigenari A, Okudaira Y, Kikkawa E, Oka A, Ota M, Mitsunaga S, Kulski JK, Inoko H, Shiina T. HLA-DRB1, -DRB3, -DRB4 and -DRB5 genotyping at a super-high resolution level by long range PCR and high-throughput sequencing. Tissue Antigens. 2014 Jan;83(1):10-6. doi: 10.1111/tan.12258.
9. Ohnuki Y, Takahashi K, Iijima E, Takahashi W, Suzuki S, Ozaki Y, Kitao R, Mihara M, Ishihara T, Nakamura M, Sawano Y, Goto Y, Izumi S, Kulski JK, Shiina T, Takizawa S. Multiple deletions in mitochondrial DNA in a patient with progressive external ophthalmoplegia, leukoencephalopathy and hypogonadism. Intern Med. 2014;53(12):1365-9.

総説

1. Kulski JK, Inoko H, Shiina T. Human Leukocyte Antigen (ed. Yongzhi Xi) In phase HLA genotyping by next generation sequencing. A comparison between two massively parallel sequencing bench-top systems, the Roche GS Junior and Ion Torrent PGM. Intech, Croatia, 2014; Chapter 5.
2. 椎名 隆. HLA DNAタイピング法のパラダイムシフト. 医学のあゆみ. 2014. 251: 273-278.