Department of Molecular Life Science, Tokai University School of Medicine
東海大学医学部 基礎医学系分子生命科学 English
 

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所在地
東海大学医学部
基礎医学系分子生命科学
〒259-1193
神奈川県伊勢原市下糟屋143
電話:0463-93-1121


健康医科学産業推進協議会
東海大学「産学連携プロジェクト・健康医科学研究」
最近の主な研究業績

2009年

  • Miyazawa M, Ishii T, Ysuda K, Noda S, Onouchi H, Hartman PS, Ishii N. The role of mitochondrial superoxide anion (O2-) production on physiological aging in C57BL/6J mice. J. Radiat. Res., 50: 73-82, 2009 (IF= 1.683)
  • Nishizaki Y. Kuwahira I. Kawada H. Kubo A. Kataoka K. Tanaka S. Sueno T. Isozaki M. Kobayashi H. Nakamura Y. Tanino R. Ishii N. Inoko H. Beneficial effects of medical advice provided to elderly persons under the Anti-aging health check-up system at Tokai University Tokyo hospital. Tokai J Exp Clin Med. 34(4): 142-151, 2009

2011年

  • Takahashi Y, Daitoku H, Hirota K, Tamiya H, Yokoyama A, kako K, Nagashima Y, Nakamura A, Shimada T, Watanabe S, Yamagata K., Yasuda K, Ishii N, Fukamizu A: Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16. Cell Metabolism 13: 505-516, 2011 (IF= 13.668)
  • Fujii M, Yasuda K, Hartman PS, Ayusawa D, Ishii N: A mutation in a mitochondrial dehydrogenase/reductase gene causes an increased sensitivity to oxidative stress and mitochondrial defects in the nematode Caenorhabditis elegans. Genes to Cells 16: 1022-1034, 2011 (IF= 2.680)
  • Ishii T, Miyazawa M, Onodera A, Yasuda K, Kawabe N, Kirinashizawa M, Yoshimura S, Maruyama N, Hartman PS, Ishii N: Mitochondrial reactive oxygen species generation by the SDHC V69E mutation causes low birth weight and neonatal growth retardation. Mitochondrion 11: 155-165, 2011 (IF= 3.615)
  • Yasuda K, Hartman PS, Ishii T, Suda H, Akatsuka A, Shoyama T, Miyazawa M, Ishii N: Interrelationships between mitochondrial fusion, energy metabolism and oxidative stress during development in Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 404: 751-755, 2011 (IF= 2.484)
  • Downing C, Biers J, Larson C, Kimball A, Wright H, Ishii T, Gilliam D, Johnson T: Genetic and maternal effects on valproic acid teratogenesis in C57BL/6J and DBA/2J mice. Toxicol. Sci. 116: 632-639, 2011 (IF= 4.652)
  • Nishizaki Y. Kubo A. Kuwahira I. Tanino R. Sueno T. Kuroda E. Ogawa T. Ishii N: A proposal research for new health check-up items focusing on the future super-aging society in Japan. Health Evaluation and Promotion. 38: 537-546, 2011

2012年

  • Nishizaki Y, Kubo A, Kuwahira I, Kuroda E, Nigou N, Motegi S,Yamada C, Sueno T, Ogawa T, Tanino R, Ishii N: Anti-aging health check-up system: For the prevention of potentially progress aging related disadvantageous changes in elderly. Health Evaluation and Promotion. 39: 519-529, 2012
  • Nishizaki Y, Kuwahira I. Kubo A, Tanino R, Ishii N: A questionnaire survey on the awareness of recipients of a general health check-up for anti-aging medicine: From knowledge to behavior modification. Health Evaluation and Promotion. 39: 519-529, 2012
  • Onouchi H, Ishii T, Miyazawa M, Uchino Y, Yasuda K, Hartman PS, Kawai K, Tsubota K, Ishii N: Mitochondrial superoxide anion overproduction in Tet-mev-1 transgenic mice accelerates age-dependent corneal cell dysfunction. IOVS 2012 (in press) (IF= 3.597)
  • Uchino Y, Kawakita T, Miyazawa M, Ishii T, Onouchi H, Yasuda K, Ogawa Y, Shimamura S, Ishii N, Tsubota K: Oxidative stress induced inflammation initiates functional decline of tear production. PLoS One 2012 (in press) (IF= 4.092)